Abstract
| Original language | English |
|---|---|
| Pages (from-to) | e8-e14 |
| Journal | Clinical oral implants research |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 7 Nov 2016 |
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Keywords
- METIS-308079
- IR-95715
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Evaluation of novel resorbable membranes for bone augmentation in a rat model. / Zeng, N.; van Leeuwen, A.C.; Yuan, Huipin; Bos, R.R.M.; Grijpma, Dirk W.; Kuijer, R.
In: Clinical oral implants research, Vol. 27, No. 2, 07.11.2016, p. e8-e14.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Evaluation of novel resorbable membranes for bone augmentation in a rat model
AU - Zeng, N.
AU - van Leeuwen, A.C.
AU - Yuan, Huipin
AU - Bos, R.R.M.
AU - Grijpma, Dirk W.
AU - Kuijer, R.
N1 - Early View (Online Version of Record published before inclusion in an issue)
PY - 2016/11/7
Y1 - 2016/11/7
N2 - Objectives Our study compared two novel, biodegradable poly(trimethylene carbonate) (PTMC) barrier membranes to clinically applied barrier membranes in maintaining volume of block autologous bone grafts in a rat mandible model. Material and methods Two hundred and forty rats were included in this study. Block autologous bone grafts of 5 mm in diameter were harvested from the mandibular angles and transplanted onto the contralateral side. The bone grafts were either covered with a membrane or left uncovered. The applied membranes included pure PTMC membranes, biphasic calcium phosphate (BCP) incorporated PTMC composite membranes, expanded poly(tetrafluoroethylene) (e-PTFE) membranes (Tex) and collagen membranes (Geistlich Bio-Gide). After 2, 4 and 12 weeks, the rat mandibles were retrieved and analysed by histological evaluation and μCT quantification. Results The histological evaluation revealed that in time the block autologous bone graft was well integrated to the recipient bone via gradually maturing newly formed bone and did not show signs of resorption, independent of membrane coverage or types of membrane. μCT quantification showed the volume of the bone graft and recipient bone together was maintained by new bone formation and recipient bone resorption. Conclusions Our study showed that the use of PTMC membranes and PTMC-BCP composite membranes resulted in similar bone remodelling to the collagen membranes and e-PTFE membranes and that the use of barrier membranes did not interfere with bone remodelling of the bone grafts and recipient bones. However, the used barrier membranes seemed not to contribute in maintaining the volume of block autologous bone grafts
AB - Objectives Our study compared two novel, biodegradable poly(trimethylene carbonate) (PTMC) barrier membranes to clinically applied barrier membranes in maintaining volume of block autologous bone grafts in a rat mandible model. Material and methods Two hundred and forty rats were included in this study. Block autologous bone grafts of 5 mm in diameter were harvested from the mandibular angles and transplanted onto the contralateral side. The bone grafts were either covered with a membrane or left uncovered. The applied membranes included pure PTMC membranes, biphasic calcium phosphate (BCP) incorporated PTMC composite membranes, expanded poly(tetrafluoroethylene) (e-PTFE) membranes (Tex) and collagen membranes (Geistlich Bio-Gide). After 2, 4 and 12 weeks, the rat mandibles were retrieved and analysed by histological evaluation and μCT quantification. Results The histological evaluation revealed that in time the block autologous bone graft was well integrated to the recipient bone via gradually maturing newly formed bone and did not show signs of resorption, independent of membrane coverage or types of membrane. μCT quantification showed the volume of the bone graft and recipient bone together was maintained by new bone formation and recipient bone resorption. Conclusions Our study showed that the use of PTMC membranes and PTMC-BCP composite membranes resulted in similar bone remodelling to the collagen membranes and e-PTFE membranes and that the use of barrier membranes did not interfere with bone remodelling of the bone grafts and recipient bones. However, the used barrier membranes seemed not to contribute in maintaining the volume of block autologous bone grafts
KW - METIS-308079
KW - IR-95715
U2 - 10.1111/clr.12519
DO - 10.1111/clr.12519
M3 - Article
VL - 27
SP - e8-e14
JO - Clinical oral implants research
JF - Clinical oral implants research
SN - 0905-7161
IS - 2
ER -