Evaluation of the cognitive-motor performance of adults with Duchenne Muscular Dystrophy in a hand-related task

Kostas Nizamis*, Wouter Schutte, Jan J Grutters, Jasper Goseling, Noortje H.M. Rijken, Bart F.J.M. Koopman

*Corresponding author for this work

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Abstract

Duchenne muscular Dystrophy (DMD) is a progressive degenerative muscle disease, affecting, among others, the upper extremities. Effective hand rehabilitation can improve the hand function of people with DMD. To reach this goal, we first need to gain more insight into the hand cognitive-motor performance of people with DMD. This is the first study employing a systematic analysis on multi-finger, cognitive-motor performance of people with DMD. For this purpose, we propose an active dynamic visuo-motor task. The task employed six visual stimuli, a subset of which was activated at each trial. The stimuli were activated with a frequency of 1, 2, 3 and 4 Hz. Eight healthy participants and three participants with DMD performed the task. Additionally, the healthy participants performed seven sessions, and we assessed the training effects. Task-related cognitive-motor performance was evaluated using information transfer rate (ITR) and perceived workload. Regarding ITR, healthy participants performed significantly better than DMD participants; however, this was more evident for trials involving more than three fingers. Workload showed no difference between the healthy and the DMD groups. Healthy participants significantly improved their performance during training. Our results suggest that hand rehabilitation of people with DMD should consider multi-finger dynamic training. However, additional research with more people with DMD is needed for further generalization of our conclusions.
Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalPLoS ONE
Volume15
Issue number1
DOIs
Publication statusPublished - 31 Jan 2020

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muscular dystrophy
Duchenne Muscular Dystrophy
hands
Hand
Patient rehabilitation
Healthy Volunteers
Fingers
rehabilitation (people)
information exchange
Workload
Muscle
Rehabilitation
muscular diseases
Upper Extremity
Muscles

Cite this

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title = "Evaluation of the cognitive-motor performance of adults with Duchenne Muscular Dystrophy in a hand-related task",
abstract = "Duchenne muscular Dystrophy (DMD) is a progressive degenerative muscle disease, affecting, among others, the upper extremities. Effective hand rehabilitation can improve the hand function of people with DMD. To reach this goal, we first need to gain more insight into the hand cognitive-motor performance of people with DMD. This is the first study employing a systematic analysis on multi-finger, cognitive-motor performance of people with DMD. For this purpose, we propose an active dynamic visuo-motor task. The task employed six visual stimuli, a subset of which was activated at each trial. The stimuli were activated with a frequency of 1, 2, 3 and 4 Hz. Eight healthy participants and three participants with DMD performed the task. Additionally, the healthy participants performed seven sessions, and we assessed the training effects. Task-related cognitive-motor performance was evaluated using information transfer rate (ITR) and perceived workload. Regarding ITR, healthy participants performed significantly better than DMD participants; however, this was more evident for trials involving more than three fingers. Workload showed no difference between the healthy and the DMD groups. Healthy participants significantly improved their performance during training. Our results suggest that hand rehabilitation of people with DMD should consider multi-finger dynamic training. However, additional research with more people with DMD is needed for further generalization of our conclusions.",
author = "Kostas Nizamis and Wouter Schutte and Grutters, {Jan J} and Jasper Goseling and Rijken, {Noortje H.M.} and Koopman, {Bart F.J.M.}",
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Evaluation of the cognitive-motor performance of adults with Duchenne Muscular Dystrophy in a hand-related task. / Nizamis, Kostas; Schutte, Wouter; Grutters, Jan J; Goseling, Jasper; Rijken, Noortje H.M.; Koopman, Bart F.J.M.

In: PLoS ONE, Vol. 15, No. 1, 31.01.2020, p. 1-17.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Rijken, Noortje H.M.

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