Evaluation of the finger wrinkling test: A pilot study

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
29 Downloads (Pure)

Abstract

Purpose: Tilt table testing mainly evaluates the systemic cardiovascular part of the autonomic nervous system, while it is assumed that the finger wrinkling test assesses the peripheral part of the autonomic nervous system. In this study we explored whether the finger wrinkling test could be a useful test for autonomic dysfunction and whether the clinical evaluation of wrinkling can be improved by digital analysis of photographs. Methods: As much as 20 healthy subjects and 15 patients underwent tilt table testing and finger wrinkling testing. During the finger wrinkling test the right hand was immersed in water at 40°C. The degree of wrinkling was assessed with a 5-point clinical scale at baseline, 5, 15 and 30 min of immersion. Photographs were taken at the same intervals. Several features were evaluated using digital analysis: length and gradient of automatically detected wrinkle and mean, maximum, minimum, variance and derivative of grey value of pixels. Results: Clinical scoring of wrinkling allowed differentiation between healthy subjects and patients with a normal and an abnormal response to tilt table testing. Relevant features obtained with digital analysis were mean grey value and the gradient of automatically detected wrinkle. McNemar’s test showed no difference in test results between the tilt table test and the finger wrinkling test with a kappa of 0.68. Conclusion: The finger wrinkling test can be used as a screening test before tilt table testing. Visual evaluation of wrinkling is still superior to digital analysis of photographs.
Original languageEnglish
Pages (from-to)249-253
JournalClinical autonomic research
Volume20
Issue number4
DOIs
Publication statusPublished - 2010

Fingerprint

Fingers
Tilt-Table Test
Autonomic Nervous System
Healthy Volunteers
Immersion
Hand
Water

Keywords

  • METIS-272825
  • Autonomic dysfunction - Tilt table test - Finger wrinkling test - Digital analysis
  • IR-77912

Cite this

@article{7c2cb4d4471541e5b5f5a4dcec230f51,
title = "Evaluation of the finger wrinkling test: A pilot study",
abstract = "Purpose: Tilt table testing mainly evaluates the systemic cardiovascular part of the autonomic nervous system, while it is assumed that the finger wrinkling test assesses the peripheral part of the autonomic nervous system. In this study we explored whether the finger wrinkling test could be a useful test for autonomic dysfunction and whether the clinical evaluation of wrinkling can be improved by digital analysis of photographs. Methods: As much as 20 healthy subjects and 15 patients underwent tilt table testing and finger wrinkling testing. During the finger wrinkling test the right hand was immersed in water at 40°C. The degree of wrinkling was assessed with a 5-point clinical scale at baseline, 5, 15 and 30 min of immersion. Photographs were taken at the same intervals. Several features were evaluated using digital analysis: length and gradient of automatically detected wrinkle and mean, maximum, minimum, variance and derivative of grey value of pixels. Results: Clinical scoring of wrinkling allowed differentiation between healthy subjects and patients with a normal and an abnormal response to tilt table testing. Relevant features obtained with digital analysis were mean grey value and the gradient of automatically detected wrinkle. McNemar’s test showed no difference in test results between the tilt table test and the finger wrinkling test with a kappa of 0.68. Conclusion: The finger wrinkling test can be used as a screening test before tilt table testing. Visual evaluation of wrinkling is still superior to digital analysis of photographs.",
keywords = "METIS-272825, Autonomic dysfunction - Tilt table test - Finger wrinkling test - Digital analysis, IR-77912",
author = "{van Barneveld}, S. and {van der Palen}, {Jacobus Adrianus Maria} and {van Putten}, {Michel Johannes Antonius Maria}",
note = "Open Access",
year = "2010",
doi = "10.1007/s10286-010-0071-9",
language = "English",
volume = "20",
pages = "249--253",
journal = "Clinical autonomic research",
issn = "0959-9851",
publisher = "Dietrich Steinkopff Verlag",
number = "4",

}

Evaluation of the finger wrinkling test: A pilot study. / van Barneveld, S.; van der Palen, Jacobus Adrianus Maria; van Putten, Michel Johannes Antonius Maria.

In: Clinical autonomic research, Vol. 20, No. 4, 2010, p. 249-253.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Evaluation of the finger wrinkling test: A pilot study

AU - van Barneveld, S.

AU - van der Palen, Jacobus Adrianus Maria

AU - van Putten, Michel Johannes Antonius Maria

N1 - Open Access

PY - 2010

Y1 - 2010

N2 - Purpose: Tilt table testing mainly evaluates the systemic cardiovascular part of the autonomic nervous system, while it is assumed that the finger wrinkling test assesses the peripheral part of the autonomic nervous system. In this study we explored whether the finger wrinkling test could be a useful test for autonomic dysfunction and whether the clinical evaluation of wrinkling can be improved by digital analysis of photographs. Methods: As much as 20 healthy subjects and 15 patients underwent tilt table testing and finger wrinkling testing. During the finger wrinkling test the right hand was immersed in water at 40°C. The degree of wrinkling was assessed with a 5-point clinical scale at baseline, 5, 15 and 30 min of immersion. Photographs were taken at the same intervals. Several features were evaluated using digital analysis: length and gradient of automatically detected wrinkle and mean, maximum, minimum, variance and derivative of grey value of pixels. Results: Clinical scoring of wrinkling allowed differentiation between healthy subjects and patients with a normal and an abnormal response to tilt table testing. Relevant features obtained with digital analysis were mean grey value and the gradient of automatically detected wrinkle. McNemar’s test showed no difference in test results between the tilt table test and the finger wrinkling test with a kappa of 0.68. Conclusion: The finger wrinkling test can be used as a screening test before tilt table testing. Visual evaluation of wrinkling is still superior to digital analysis of photographs.

AB - Purpose: Tilt table testing mainly evaluates the systemic cardiovascular part of the autonomic nervous system, while it is assumed that the finger wrinkling test assesses the peripheral part of the autonomic nervous system. In this study we explored whether the finger wrinkling test could be a useful test for autonomic dysfunction and whether the clinical evaluation of wrinkling can be improved by digital analysis of photographs. Methods: As much as 20 healthy subjects and 15 patients underwent tilt table testing and finger wrinkling testing. During the finger wrinkling test the right hand was immersed in water at 40°C. The degree of wrinkling was assessed with a 5-point clinical scale at baseline, 5, 15 and 30 min of immersion. Photographs were taken at the same intervals. Several features were evaluated using digital analysis: length and gradient of automatically detected wrinkle and mean, maximum, minimum, variance and derivative of grey value of pixels. Results: Clinical scoring of wrinkling allowed differentiation between healthy subjects and patients with a normal and an abnormal response to tilt table testing. Relevant features obtained with digital analysis were mean grey value and the gradient of automatically detected wrinkle. McNemar’s test showed no difference in test results between the tilt table test and the finger wrinkling test with a kappa of 0.68. Conclusion: The finger wrinkling test can be used as a screening test before tilt table testing. Visual evaluation of wrinkling is still superior to digital analysis of photographs.

KW - METIS-272825

KW - Autonomic dysfunction - Tilt table test - Finger wrinkling test - Digital analysis

KW - IR-77912

U2 - 10.1007/s10286-010-0071-9

DO - 10.1007/s10286-010-0071-9

M3 - Article

VL - 20

SP - 249

EP - 253

JO - Clinical autonomic research

JF - Clinical autonomic research

SN - 0959-9851

IS - 4

ER -