Eversion technique versus traditional carotid endarterectomy with patch angioplasty: a systematic review with meta-analyses and trial sequential analysis

Martijn S. Marsman*, Jørn Wetterslev, Patrick W.H.E. Vriens, Ronald L.A.W. Bleys, Abdelkarime Kh Jahrome, Frans L. Moll, Frederik Keus, Michel M.P.J. Reijnen, Giel G. Koning

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Introduction: The use of an ‘eversion’ technique is not unequivocally proven to be superior to carotid endarterectomy with patch angioplasty. An up-to-date systematic review is needed for evaluation of benefits and harms of these two techniques. Methods: RCTs comparing eversion technique versus endarterectomy with patch angioplasty in patients with a symptomatic and significant (≥50 %) stenosis of the internal carotid artery were enrolled. Primary outcomes were all-cause mortality rate, health-related quality of life and serious adverse events. Secondary outcomes included 30-day stroke and mortality rate, (a) symptomatic arterial occlusion or restenosis, and adverse events not critical for decision making. Results: Four RCTs were included with 1272 surgical procedures for carotid stenosis; eversion technique n = 643 and carotid endarterectomy with patch closure n = 629. Meta-analysis comparing both techniques showed, with a very low certainty of evidence, that eversion technique might decrease the number of patients with serious adverse events (RR 0.47; 95% CI 0.34 to 0.64; p ≤ 0.01). However, no difference was found on the other outcomes. TSA demonstrated that the required information sizes were far from being reached for these patient-important outcomes. All patient-relevant outcomes were at low certainty of evidence according to GRADE. Conclusions: This systematic review showed no conclusive evidence of any difference between eversion technique and carotid endarterectomy with patch angioplasty in carotid surgery. These conclusions are based on data obtained in trials with very low certainty according to GRADE and should therefore be interpreted cautiously. Until conclusive evidence is obtained, the standard of care according to ESVS guidelines should not be abandoned.

Original languageEnglish
Pages (from-to)99-110
Number of pages12
JournalSurgery Open Science
Volume13
DOIs
Publication statusPublished - Jun 2023

Keywords

  • Blood pressure
  • Carotid endarterectomy
  • Eversion technique
  • Patch
  • Stenosis
  • Systematic review

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