Evidence for the existence of homolateral and contralateral projections from the substantia nigra to the subthalamic nucleus in the rat

E.A.J.F. Lakke, Tjitske Heida, K.G. Usunoff, Enrico Marani

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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Abstract

Hemichorea/ballism is a rare neurological disorder but the crucial involvement of the subthalamic nucleus (STN) in its pathophysiology is appreciated since decades. The idiopathic Parkinson’s disease is a common neurodegenerative disorder but the key role of the STN in the pathophysiological origin of the parkinsonian state became only recently evident. The STN was believed to exert an inhibitory, probably – GABA-mediated, effect on its projection nuclei, and this belief is one of the major reasons to overlook the involvement of the STN in the parkinsonian pathophysiology. It is now firmly established that the STN projection neurons are glutamatergic, excitatory, and heavily innervate by widely branching axons of the substantia nigra (SN), the internal pallidal segment (GPI), followed by the external pallidal segment (GPE) and the pedunculopontine tegmental nucleus (PPN).
Original languageUndefined
Title of host publicationProceedings of the14th Meeting of the World Society for Stereotactic and Functional Neurosurgery, WSSFN
EditorsM. Meglio
Place of PublicationPianoro, Italy
PublisherWorld Society for Sterotactic and Functional Neurosurgery
Pages1-2
Number of pages2
ISBN (Print)978-88-7587-158-1
Publication statusPublished - 14 May 2005

Publication series

Name
PublisherMedimond

Keywords

  • IR-76576
  • EWI-19930
  • METIS-226390

Cite this

Lakke, E. A. J. F., Heida, T., Usunoff, K. G., & Marani, E. (2005). Evidence for the existence of homolateral and contralateral projections from the substantia nigra to the subthalamic nucleus in the rat. In M. Meglio (Ed.), Proceedings of the14th Meeting of the World Society for Stereotactic and Functional Neurosurgery, WSSFN (pp. 1-2). Pianoro, Italy: World Society for Sterotactic and Functional Neurosurgery.
Lakke, E.A.J.F. ; Heida, Tjitske ; Usunoff, K.G. ; Marani, Enrico. / Evidence for the existence of homolateral and contralateral projections from the substantia nigra to the subthalamic nucleus in the rat. Proceedings of the14th Meeting of the World Society for Stereotactic and Functional Neurosurgery, WSSFN. editor / M. Meglio. Pianoro, Italy : World Society for Sterotactic and Functional Neurosurgery, 2005. pp. 1-2
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abstract = "Hemichorea/ballism is a rare neurological disorder but the crucial involvement of the subthalamic nucleus (STN) in its pathophysiology is appreciated since decades. The idiopathic Parkinson’s disease is a common neurodegenerative disorder but the key role of the STN in the pathophysiological origin of the parkinsonian state became only recently evident. The STN was believed to exert an inhibitory, probably – GABA-mediated, effect on its projection nuclei, and this belief is one of the major reasons to overlook the involvement of the STN in the parkinsonian pathophysiology. It is now firmly established that the STN projection neurons are glutamatergic, excitatory, and heavily innervate by widely branching axons of the substantia nigra (SN), the internal pallidal segment (GPI), followed by the external pallidal segment (GPE) and the pedunculopontine tegmental nucleus (PPN).",
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Lakke, EAJF, Heida, T, Usunoff, KG & Marani, E 2005, Evidence for the existence of homolateral and contralateral projections from the substantia nigra to the subthalamic nucleus in the rat. in M Meglio (ed.), Proceedings of the14th Meeting of the World Society for Stereotactic and Functional Neurosurgery, WSSFN. World Society for Sterotactic and Functional Neurosurgery, Pianoro, Italy, pp. 1-2.

Evidence for the existence of homolateral and contralateral projections from the substantia nigra to the subthalamic nucleus in the rat. / Lakke, E.A.J.F.; Heida, Tjitske; Usunoff, K.G.; Marani, Enrico.

Proceedings of the14th Meeting of the World Society for Stereotactic and Functional Neurosurgery, WSSFN. ed. / M. Meglio. Pianoro, Italy : World Society for Sterotactic and Functional Neurosurgery, 2005. p. 1-2.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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T1 - Evidence for the existence of homolateral and contralateral projections from the substantia nigra to the subthalamic nucleus in the rat

AU - Lakke, E.A.J.F.

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AU - Marani, Enrico

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N2 - Hemichorea/ballism is a rare neurological disorder but the crucial involvement of the subthalamic nucleus (STN) in its pathophysiology is appreciated since decades. The idiopathic Parkinson’s disease is a common neurodegenerative disorder but the key role of the STN in the pathophysiological origin of the parkinsonian state became only recently evident. The STN was believed to exert an inhibitory, probably – GABA-mediated, effect on its projection nuclei, and this belief is one of the major reasons to overlook the involvement of the STN in the parkinsonian pathophysiology. It is now firmly established that the STN projection neurons are glutamatergic, excitatory, and heavily innervate by widely branching axons of the substantia nigra (SN), the internal pallidal segment (GPI), followed by the external pallidal segment (GPE) and the pedunculopontine tegmental nucleus (PPN).

AB - Hemichorea/ballism is a rare neurological disorder but the crucial involvement of the subthalamic nucleus (STN) in its pathophysiology is appreciated since decades. The idiopathic Parkinson’s disease is a common neurodegenerative disorder but the key role of the STN in the pathophysiological origin of the parkinsonian state became only recently evident. The STN was believed to exert an inhibitory, probably – GABA-mediated, effect on its projection nuclei, and this belief is one of the major reasons to overlook the involvement of the STN in the parkinsonian pathophysiology. It is now firmly established that the STN projection neurons are glutamatergic, excitatory, and heavily innervate by widely branching axons of the substantia nigra (SN), the internal pallidal segment (GPI), followed by the external pallidal segment (GPE) and the pedunculopontine tegmental nucleus (PPN).

KW - IR-76576

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Lakke EAJF, Heida T, Usunoff KG, Marani E. Evidence for the existence of homolateral and contralateral projections from the substantia nigra to the subthalamic nucleus in the rat. In Meglio M, editor, Proceedings of the14th Meeting of the World Society for Stereotactic and Functional Neurosurgery, WSSFN. Pianoro, Italy: World Society for Sterotactic and Functional Neurosurgery. 2005. p. 1-2