Evidence for the existence of homolateral and contralateral projections from the substantia nigra to the subthalamic nucleus in the rat

E.A.J.F. Lakke, Tjitske Heida, K.G. Usunoff, Enrico Marani

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    Hemichorea/ballism is a rare neurological disorder but the crucial involvement of the subthalamic nucleus (STN) in its pathophysiology is appreciated since decades. The idiopathic Parkinson’s disease is a common neurodegenerative disorder but the key role of the STN in the pathophysiological origin of the parkinsonian state became only recently evident. The STN was believed to exert an inhibitory, probably – GABA-mediated, effect on its projection nuclei, and this belief is one of the major reasons to overlook the involvement of the STN in the parkinsonian pathophysiology. It is now firmly established that the STN projection neurons are glutamatergic, excitatory, and heavily innervate by widely branching axons of the substantia nigra (SN), the internal pallidal segment (GPI), followed by the external pallidal segment (GPE) and the pedunculopontine tegmental nucleus (PPN).
    Original languageUndefined
    Title of host publicationProceedings of the14th Meeting of the World Society for Stereotactic and Functional Neurosurgery, WSSFN
    EditorsM. Meglio
    Place of PublicationPianoro, Italy
    PublisherWorld Society for Sterotactic and Functional Neurosurgery
    Number of pages2
    ISBN (Print)978-88-7587-158-1
    Publication statusPublished - 14 May 2005

    Publication series



    • IR-76576
    • EWI-19930
    • METIS-226390

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