TY - JOUR
T1 - Excitation coil for sentinel lymph node harvesting
T2 - design, digital twin and prototype
AU - Molenaar, L.
AU - Horstman-van de Loosdrecht, M. M.
AU - Krooshoop, H. J.G.
AU - Wesselink, R. J.H.
AU - Ten Haken, B.
AU - Broeders, I. A.M.J.
AU - Alic, L.
N1 - Funding Information:
*This research has been sponsored by the Netherlands Organization for scientific Research (NWO), under the research program Magnetic Sensing for Laparoscopy(MagLap), withproject number 14322.
Publisher Copyright:
© 2022 IEEE.
PY - 2022/9/8
Y1 - 2022/9/8
N2 - A recently developed prototype (Laparoscopic Differential Magnetometer, in short LapDiffMag) identifies magnetic tracer accumulated inside sentinel lymph nodes (SLNs) during clinical laparoscopic procedures. The LapDiffMag relies on excitation of superparamagnetic iron oxide nanoparticles (SPIONs) and subsequent laparoscopic detection based on a nonlinear detection principle. The prototype uses an excitation coil to generate a magnetic field needed to activate SPIONs. This study reports on the process of developing a new excitation coil by describing the design choices based upon clinical requirements, by modeling delivered magnetic field using digital twin, and by comparing the magnetic fields of modeled and manufactured prototype. Digital twin technology was used to produce relevant and reliable data to demonstrate the safety and effectiveness of the excitation coil. The magnetic field originating from manufactured prototype was validated at two different heights above the excitation coil and have shown a good concordance to the data generated by its digital twin. Clinical Relevance- Current standard-of-care for a variety of tumor types consists of minimally invasive radical resection of primary tumor and regional lymph nodes (LNs). The newly introduced excitation coil will (after full validation) enable minimally invasive harvesting of sentinel LNs by means of magnetic tracer detection.
AB - A recently developed prototype (Laparoscopic Differential Magnetometer, in short LapDiffMag) identifies magnetic tracer accumulated inside sentinel lymph nodes (SLNs) during clinical laparoscopic procedures. The LapDiffMag relies on excitation of superparamagnetic iron oxide nanoparticles (SPIONs) and subsequent laparoscopic detection based on a nonlinear detection principle. The prototype uses an excitation coil to generate a magnetic field needed to activate SPIONs. This study reports on the process of developing a new excitation coil by describing the design choices based upon clinical requirements, by modeling delivered magnetic field using digital twin, and by comparing the magnetic fields of modeled and manufactured prototype. Digital twin technology was used to produce relevant and reliable data to demonstrate the safety and effectiveness of the excitation coil. The magnetic field originating from manufactured prototype was validated at two different heights above the excitation coil and have shown a good concordance to the data generated by its digital twin. Clinical Relevance- Current standard-of-care for a variety of tumor types consists of minimally invasive radical resection of primary tumor and regional lymph nodes (LNs). The newly introduced excitation coil will (after full validation) enable minimally invasive harvesting of sentinel LNs by means of magnetic tracer detection.
KW - 22/4 OA procedure
UR - http://www.scopus.com/inward/record.url?scp=85138127588&partnerID=8YFLogxK
U2 - 10.1109/EMBC48229.2022.9871415
DO - 10.1109/EMBC48229.2022.9871415
M3 - Article
C2 - 36086020
AN - SCOPUS:85138127588
SN - 2694-0604
VL - 2022
SP - 4402
EP - 4406
JO - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
JF - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
ER -