TY - JOUR
T1 - Exercise induces gastric ischemia in healthy volunteers
T2 - A tonometry study
AU - Otte, Johannes A.
AU - Oostveen, Ellie
AU - Geelkerken, Robert H.
AU - Groeneveld, A. B.Johan
AU - Kolkman, Jeroen J.
PY - 2001/8/7
Y1 - 2001/8/7
N2 - Heavy physical exercise may cause gastrointestinal signs and symptoms, and, although splanchnic blood flow may decrease through redistribution by more than 50%, it is unclear whether these signs and symptoms relate to gastrointestinal ischemia. In 10 healthy volunteers, we studied the effect of exercise on gastric mucosal perfusion adequacy using air tonometry. Two relatively short (10 min) exercise stages were conducted on a cycle ergometer, aiming for 80 and 100% of maximum heart rate, respectively. The intragastric-arterial PCO2 gradient (ΔPCO2) was elevated by 1.1 ± 1.0 kPa over baseline values (-0.1 ± 0.3 kPa) only after maximal exercise (P < 0.001). ΔPCO2 positively correlated with the arterial lactate level taken as an index of exercise intensity (Spearman's rank test: r = 0.76, P < 0.0001). By bilinear regression analysis, a lactate level of 12 mmol/l, above which a sharp rise in the ΔPCO2 occurred, was calculated. We conclude that, in healthy volunteers with normal splanchnic vasculature, gastric ischemia may develop during maximal exercise as judged from intragastric PCO2 tonometry.
AB - Heavy physical exercise may cause gastrointestinal signs and symptoms, and, although splanchnic blood flow may decrease through redistribution by more than 50%, it is unclear whether these signs and symptoms relate to gastrointestinal ischemia. In 10 healthy volunteers, we studied the effect of exercise on gastric mucosal perfusion adequacy using air tonometry. Two relatively short (10 min) exercise stages were conducted on a cycle ergometer, aiming for 80 and 100% of maximum heart rate, respectively. The intragastric-arterial PCO2 gradient (ΔPCO2) was elevated by 1.1 ± 1.0 kPa over baseline values (-0.1 ± 0.3 kPa) only after maximal exercise (P < 0.001). ΔPCO2 positively correlated with the arterial lactate level taken as an index of exercise intensity (Spearman's rank test: r = 0.76, P < 0.0001). By bilinear regression analysis, a lactate level of 12 mmol/l, above which a sharp rise in the ΔPCO2 occurred, was calculated. We conclude that, in healthy volunteers with normal splanchnic vasculature, gastric ischemia may develop during maximal exercise as judged from intragastric PCO2 tonometry.
KW - Exercise testing
KW - Gastric mucosal perfusion
KW - Intragastric carbon dioxide pressure
UR - http://www.scopus.com/inward/record.url?scp=0034916535&partnerID=8YFLogxK
U2 - 10.1152/jappl.2001.91.2.866
DO - 10.1152/jappl.2001.91.2.866
M3 - Article
C2 - 11457804
AN - SCOPUS:0034916535
SN - 8750-7587
VL - 91
SP - 866
EP - 871
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 2
ER -