Experience-Driven plasticity in binocular vision

P. Christiaan Klink, Jan W. Brascamp, Randolph Blake, Richard Jack Anton van Wezel

    Research output: Contribution to journalArticleAcademicpeer-review

    53 Citations (Scopus)
    11 Downloads (Pure)

    Abstract

    Experience-driven neuronal plasticity allows the brain to adapt its functional connectivity to recent sensory input. Here we use binocular rivalry [1], an experimental paradigm in which conflicting images are presented to the individual eyes, to demonstrate plasticity in the neuronal mechanisms that convert visual information from two separated retinas into single perceptual experiences. Perception during binocular rivalry tended to initially consist of alternations between exclusive representations of monocularly defined images, but upon prolonged exposure, mixture percepts became more prevalent. The completeness of suppression, reflected in the incidence of mixture percepts, plausibly reflects the strength of inhibition that likely plays a role in binocular rivalry [2]. Recovery of exclusivity was possible but required highly specific binocular stimulation. Documenting the prerequisites for these observed changes in perceptual exclusivity, our experiments suggest experience-driven plasticity at interocular inhibitory synapses, driven by the correlated activity (and also the lack thereof) of neurons representing the conflicting stimuli. This form of plasticity is consistent with a previously proposed but largely untested anti-Hebbian learning mechanism for inhibitory synapses in vision [[3] and [4]]. Our results implicate experience-driven plasticity as one governing principle in the neuronal organization of binocular vision.
    Original languageUndefined
    Pages (from-to)1464-1469
    Number of pages6
    JournalCurrent biology
    Volume20
    Issue number16
    DOIs
    Publication statusPublished - 24 Aug 2010

    Keywords

    • EWI-18452
    • efficacy of interocular inhibition
    • IR-73109
    • Binocular rivalry
    • METIS-277427
    • binocular fusion

    Cite this

    Klink, P. Christiaan ; Brascamp, Jan W. ; Blake, Randolph ; van Wezel, Richard Jack Anton. / Experience-Driven plasticity in binocular vision. In: Current biology. 2010 ; Vol. 20, No. 16. pp. 1464-1469.
    @article{8a2a074cee1e4fac8b208f3bf9be7cf4,
    title = "Experience-Driven plasticity in binocular vision",
    abstract = "Experience-driven neuronal plasticity allows the brain to adapt its functional connectivity to recent sensory input. Here we use binocular rivalry [1], an experimental paradigm in which conflicting images are presented to the individual eyes, to demonstrate plasticity in the neuronal mechanisms that convert visual information from two separated retinas into single perceptual experiences. Perception during binocular rivalry tended to initially consist of alternations between exclusive representations of monocularly defined images, but upon prolonged exposure, mixture percepts became more prevalent. The completeness of suppression, reflected in the incidence of mixture percepts, plausibly reflects the strength of inhibition that likely plays a role in binocular rivalry [2]. Recovery of exclusivity was possible but required highly specific binocular stimulation. Documenting the prerequisites for these observed changes in perceptual exclusivity, our experiments suggest experience-driven plasticity at interocular inhibitory synapses, driven by the correlated activity (and also the lack thereof) of neurons representing the conflicting stimuli. This form of plasticity is consistent with a previously proposed but largely untested anti-Hebbian learning mechanism for inhibitory synapses in vision [[3] and [4]]. Our results implicate experience-driven plasticity as one governing principle in the neuronal organization of binocular vision.",
    keywords = "EWI-18452, efficacy of interocular inhibition, IR-73109, Binocular rivalry, METIS-277427, binocular fusion",
    author = "Klink, {P. Christiaan} and Brascamp, {Jan W.} and Randolph Blake and {van Wezel}, {Richard Jack Anton}",
    year = "2010",
    month = "8",
    day = "24",
    doi = "10.1016/j.cub.2010.06.057",
    language = "Undefined",
    volume = "20",
    pages = "1464--1469",
    journal = "Current biology",
    issn = "0960-9822",
    publisher = "Cell Press",
    number = "16",

    }

    Experience-Driven plasticity in binocular vision. / Klink, P. Christiaan; Brascamp, Jan W.; Blake, Randolph; van Wezel, Richard Jack Anton.

    In: Current biology, Vol. 20, No. 16, 24.08.2010, p. 1464-1469.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Experience-Driven plasticity in binocular vision

    AU - Klink, P. Christiaan

    AU - Brascamp, Jan W.

    AU - Blake, Randolph

    AU - van Wezel, Richard Jack Anton

    PY - 2010/8/24

    Y1 - 2010/8/24

    N2 - Experience-driven neuronal plasticity allows the brain to adapt its functional connectivity to recent sensory input. Here we use binocular rivalry [1], an experimental paradigm in which conflicting images are presented to the individual eyes, to demonstrate plasticity in the neuronal mechanisms that convert visual information from two separated retinas into single perceptual experiences. Perception during binocular rivalry tended to initially consist of alternations between exclusive representations of monocularly defined images, but upon prolonged exposure, mixture percepts became more prevalent. The completeness of suppression, reflected in the incidence of mixture percepts, plausibly reflects the strength of inhibition that likely plays a role in binocular rivalry [2]. Recovery of exclusivity was possible but required highly specific binocular stimulation. Documenting the prerequisites for these observed changes in perceptual exclusivity, our experiments suggest experience-driven plasticity at interocular inhibitory synapses, driven by the correlated activity (and also the lack thereof) of neurons representing the conflicting stimuli. This form of plasticity is consistent with a previously proposed but largely untested anti-Hebbian learning mechanism for inhibitory synapses in vision [[3] and [4]]. Our results implicate experience-driven plasticity as one governing principle in the neuronal organization of binocular vision.

    AB - Experience-driven neuronal plasticity allows the brain to adapt its functional connectivity to recent sensory input. Here we use binocular rivalry [1], an experimental paradigm in which conflicting images are presented to the individual eyes, to demonstrate plasticity in the neuronal mechanisms that convert visual information from two separated retinas into single perceptual experiences. Perception during binocular rivalry tended to initially consist of alternations between exclusive representations of monocularly defined images, but upon prolonged exposure, mixture percepts became more prevalent. The completeness of suppression, reflected in the incidence of mixture percepts, plausibly reflects the strength of inhibition that likely plays a role in binocular rivalry [2]. Recovery of exclusivity was possible but required highly specific binocular stimulation. Documenting the prerequisites for these observed changes in perceptual exclusivity, our experiments suggest experience-driven plasticity at interocular inhibitory synapses, driven by the correlated activity (and also the lack thereof) of neurons representing the conflicting stimuli. This form of plasticity is consistent with a previously proposed but largely untested anti-Hebbian learning mechanism for inhibitory synapses in vision [[3] and [4]]. Our results implicate experience-driven plasticity as one governing principle in the neuronal organization of binocular vision.

    KW - EWI-18452

    KW - efficacy of interocular inhibition

    KW - IR-73109

    KW - Binocular rivalry

    KW - METIS-277427

    KW - binocular fusion

    U2 - 10.1016/j.cub.2010.06.057

    DO - 10.1016/j.cub.2010.06.057

    M3 - Article

    VL - 20

    SP - 1464

    EP - 1469

    JO - Current biology

    JF - Current biology

    SN - 0960-9822

    IS - 16

    ER -