Experiment and simulation of electrospray particle-flows for controlled release of drugs

J. C M Marijnissen, T. Ciach, M.-K. Müller, T. Winkels, K.B. Geerse, A. Schmidt-Ott, S. Luding*

*Corresponding author for this work

    Research output: Contribution to conferencePaperAcademicpeer-review

    3 Citations (Scopus)

    Abstract

    Electro HydroDynamic Atomisation (EHDA) disperses a liquid into small, highly charged droplets. We show that this method can be used to produce particles that release a drug at a desired rate. This is done by spraying a solution of bio-degradable polymers and an enzyme, which represents the effective drug. The release rate can be varied by modification of the polymer matrix. It is further demonstrated that the enzyme fully retains its functionality in the EHDA process. Practical use of this technique for medicine production requires a scaled-up design, which must be based on an adequate model of the particle flow in the charged droplet spray plume. As a step in this direction, the most important result is a scale-up relation that allows simulations of an experimental spray with millions of particles, using only a few thousand model particles. The experimental spray is examined with a Phase Doppler Particle Analyser (PDPA) set-up, and the resulting density and velocity profiles are compared to the numerical results. There is a qualitative agreement between experiment and model.

    Original languageEnglish
    Pages513-520
    Number of pages8
    Publication statusPublished - 1 Jan 2005
    Event5th International Workshop on Traffic and Granular Flow, TGF 2003 - Delft, Netherlands
    Duration: 1 Oct 20033 Oct 2003
    Conference number: 5

    Conference

    Conference5th International Workshop on Traffic and Granular Flow, TGF 2003
    Abbreviated titleTGF 2003
    CountryNetherlands
    CityDelft
    Period1/10/033/10/03

    Keywords

    • Aerosol particle flows
    • Discrete particle flow simulation
    • Drug release
    • Electrospray
    • Verification with experiments

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