Experimental and modeling studies on the enantio-separation of 3,5-dinitrobenzoyl-(R),(S)-leucine by continuous liquid-liquid extraction in a cascade of centrifugal contactor separators

Boelo Schuur, Jozef G.M. Winkelman, Johannes G. de Vries, Hero J. Heeres*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

75 Citations (Scopus)

Abstract

The continuous enantioselective liquid-liquid extraction of aqueous 3,5-dinitrobenzoyl-(R),(S)-leucine (AR,S) using O-(1-t-butylcarbamoyl)-11-octadecylsulfinyl-10,11-dihydro-quinine (C, a cinchona alkaloid) as extractant in 1,2-dichloroethane (DCE) was studied experimentally in a countercurrently operated pilot scale cascade of six centrifugal contactor separators (CCS) at 294K. The extractant was efficiently recovered by back-extraction in a single CCS allowing the cascade to be run continuously for 10h. The steady-state ee of AR (eeR) in the raffinate was 42% at a 99% yield, the AS was obtained with high purity (98% eeS) and a yield of 55% in the back-extraction raffinate. In total 2.23g of AS was obtained at steady-state operation from 8.11g racemate feed. Deterioration of the ee in time was not observed, demonstrating the robustness of the chemistry. The experiments were modeled using an equilibrium stage approach. The correlation between model and experiment was satisfactory. The model was applied to optimize the production of both enantiomers in >97% ee. At zero reflux, 12 stages are required for 99% ee for both enantiomers. Application of a reflux allows a 25% reduction of the total liquid flow through the system by reduction of the wash feed as well as a reduction in the number of stages from 12 to 11. With a configuration of 12 CINC-V02's operating at an aqueous feed flow of 360mL/min, the model predicts that 17.7kg racemate per week may be separated into both enantiomers with 99% ee using only 60g of extractant.

Original languageEnglish
Pages (from-to)4682-4690
Number of pages9
JournalChemical engineering science
Volume65
Issue number16
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

Keywords

  • Enantioselective
  • Extraction
  • Mathematical modeling
  • Multiphase reactors
  • Optimization
  • Process intensification

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