Experimental myringoplasty

L. Feenstra, B. W.C. Van Der Ven, F. E. Kohn, J. Feijen

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    Artificial eardrums made from biodegradable poly(D,L-lactic acid), poly(glycolic acid) and poly(β-benzyl-L-aspartate-co-L-leucine) 50/50, and made from the microporous poly(tetrafluoroethylene) and bisphenol-A poly(carbonate) membranes were implanted into the ear and as a refernce subcutaneously in rats. The implants were histologically examined for periods up to one year. From the biodegradable polymers studied the poly(β-benzyl-L-aspartate-co-L-leucine) 50/50 evoked the least tissue reaction and the newly formed tympanic membranes are the best in terms of thickness and overall integrity. The microporous poly(tetrafluoroethylene) membrane can be considered as a valuable support for the formation of a reinforced tympanic membrane.

    Original languageEnglish
    Pages (from-to)354-357
    Number of pages4
    JournalThe International journal of artificial organs
    Issue number6
    Publication statusPublished - 1 Dec 1980

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