Experimental study on band dispersion in channels structured with micropillars

M. de Pra, W.Th. Kok, Johannes G.E. Gardeniers, G. Desmet, S. Eeltink, Jan William van Nieuwkasteele, P.J. Schoenmakers

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The band dispersion in channels with an orderly pillar structure with a pressure-driven liquid flow was determined. Several channels with different geometries were etched in a silicon wafer and enclosed by a glass wafer. The microchannels obtained had the same depth, pillar disposition, and overall porosity, but different pillar diameters and channel widths. The broadening of narrow bands of a fluorescent sample solution flowing through the channels was measured using a fluorescence microscope. It was shown that the peak dispersion occurring in the channels can be much lower than in conventional packed columns, as a consequence of the higher degree of order of the solid structure. Reduced plate heights of similar to 0.2 could be obtained for (nonretained) bands. No correlation was found between the aspect ratio ( the ratio of the channel width and the pillar diameter) and band dispersion. The geometrical construction of the sidewall region was shown to play a critical role for channel performance. A good agreement was found with predictions for the optimal sidewall geometry obtained previously with simulation studies.
Original languageUndefined
Article number10.1021/ac060915h
Pages (from-to)6519-6525
Number of pages7
JournalAnalytical chemistry
Volume78
Issue number10/18
DOIs
Publication statusPublished - 15 Sep 2006

Keywords

  • EWI-8400
  • IR-63752
  • METIS-237700
  • BIOS-Micro/nanofluidics

Cite this

de Pra, M., Kok, W. T., Gardeniers, J. G. E., Desmet, G., Eeltink, S., van Nieuwkasteele, J. W., & Schoenmakers, P. J. (2006). Experimental study on band dispersion in channels structured with micropillars. Analytical chemistry, 78(10/18), 6519-6525. [10.1021/ac060915h]. https://doi.org/10.1021/ac060915h
de Pra, M. ; Kok, W.Th. ; Gardeniers, Johannes G.E. ; Desmet, G. ; Eeltink, S. ; van Nieuwkasteele, Jan William ; Schoenmakers, P.J. / Experimental study on band dispersion in channels structured with micropillars. In: Analytical chemistry. 2006 ; Vol. 78, No. 10/18. pp. 6519-6525.
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title = "Experimental study on band dispersion in channels structured with micropillars",
abstract = "The band dispersion in channels with an orderly pillar structure with a pressure-driven liquid flow was determined. Several channels with different geometries were etched in a silicon wafer and enclosed by a glass wafer. The microchannels obtained had the same depth, pillar disposition, and overall porosity, but different pillar diameters and channel widths. The broadening of narrow bands of a fluorescent sample solution flowing through the channels was measured using a fluorescence microscope. It was shown that the peak dispersion occurring in the channels can be much lower than in conventional packed columns, as a consequence of the higher degree of order of the solid structure. Reduced plate heights of similar to 0.2 could be obtained for (nonretained) bands. No correlation was found between the aspect ratio ( the ratio of the channel width and the pillar diameter) and band dispersion. The geometrical construction of the sidewall region was shown to play a critical role for channel performance. A good agreement was found with predictions for the optimal sidewall geometry obtained previously with simulation studies.",
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de Pra, M, Kok, WT, Gardeniers, JGE, Desmet, G, Eeltink, S, van Nieuwkasteele, JW & Schoenmakers, PJ 2006, 'Experimental study on band dispersion in channels structured with micropillars' Analytical chemistry, vol. 78, no. 10/18, 10.1021/ac060915h, pp. 6519-6525. https://doi.org/10.1021/ac060915h

Experimental study on band dispersion in channels structured with micropillars. / de Pra, M.; Kok, W.Th.; Gardeniers, Johannes G.E.; Desmet, G.; Eeltink, S.; van Nieuwkasteele, Jan William; Schoenmakers, P.J.

In: Analytical chemistry, Vol. 78, No. 10/18, 10.1021/ac060915h, 15.09.2006, p. 6519-6525.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Experimental study on band dispersion in channels structured with micropillars

AU - de Pra, M.

AU - Kok, W.Th.

AU - Gardeniers, Johannes G.E.

AU - Desmet, G.

AU - Eeltink, S.

AU - van Nieuwkasteele, Jan William

AU - Schoenmakers, P.J.

N1 - 10.1021/ac060915h

PY - 2006/9/15

Y1 - 2006/9/15

N2 - The band dispersion in channels with an orderly pillar structure with a pressure-driven liquid flow was determined. Several channels with different geometries were etched in a silicon wafer and enclosed by a glass wafer. The microchannels obtained had the same depth, pillar disposition, and overall porosity, but different pillar diameters and channel widths. The broadening of narrow bands of a fluorescent sample solution flowing through the channels was measured using a fluorescence microscope. It was shown that the peak dispersion occurring in the channels can be much lower than in conventional packed columns, as a consequence of the higher degree of order of the solid structure. Reduced plate heights of similar to 0.2 could be obtained for (nonretained) bands. No correlation was found between the aspect ratio ( the ratio of the channel width and the pillar diameter) and band dispersion. The geometrical construction of the sidewall region was shown to play a critical role for channel performance. A good agreement was found with predictions for the optimal sidewall geometry obtained previously with simulation studies.

AB - The band dispersion in channels with an orderly pillar structure with a pressure-driven liquid flow was determined. Several channels with different geometries were etched in a silicon wafer and enclosed by a glass wafer. The microchannels obtained had the same depth, pillar disposition, and overall porosity, but different pillar diameters and channel widths. The broadening of narrow bands of a fluorescent sample solution flowing through the channels was measured using a fluorescence microscope. It was shown that the peak dispersion occurring in the channels can be much lower than in conventional packed columns, as a consequence of the higher degree of order of the solid structure. Reduced plate heights of similar to 0.2 could be obtained for (nonretained) bands. No correlation was found between the aspect ratio ( the ratio of the channel width and the pillar diameter) and band dispersion. The geometrical construction of the sidewall region was shown to play a critical role for channel performance. A good agreement was found with predictions for the optimal sidewall geometry obtained previously with simulation studies.

KW - EWI-8400

KW - IR-63752

KW - METIS-237700

KW - BIOS-Micro/nanofluidics

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DO - 10.1021/ac060915h

M3 - Article

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