TY - JOUR
T1 - Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease
AU - van de Burgt, Alina
AU - Dibbets-Schneider, Petra
AU - Slump, Cornelis H.
AU - Scholte, Arthur J.H.A.
AU - Atsma, Douwe E.
AU - de Geus-Oei, Lioe Fee
AU - van Velden, Floris H.P.
N1 - Funding Information:
The authors thank Eli Stern, Shandra Gutierrezdiaz and Rik de Jong from GE Healthcare and Arthur van Lingen from Amsterdam University Medical Center for their contribution, meaningful discussions and suggestions.
Publisher Copyright:
© 2021, The Author(s).
Financial transaction number:
342127881
PY - 2021
Y1 - 2021
N2 - Background: Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction technique (Evolution; GE Healthcare) for the potential application of response monitoring using 99mTc-tetrofosmin SPECT/CT in patients with coronary artery disease (CAD).Methods: Acquisitions of an anthropomorphic torso phantom with cardiac insert containing defects (with varying sizes), filled with 99mTc-pertechnetate, were performed on a SPECT/CT (Discovery 670 Pro, GE Healthcare). Subsequently, volumes of interest of the defects were manually drawn on CT to assess the recovery coefficient (RC). Bull’s eye plots were composed to evaluate the uptake per segment. Finally, 99mTc-tetrofosmin SPECT/CT scans of 10 CAD patients were used to illustrate clinical application.Results: The phantom study indicated that Evolution showed convergence after 7 iterations and 10 subsets. The average repeatability deviation of all configurations was 2.91% and 3.15% (%SD mean) for filtered (Butterworth) and unfiltered data, respectively. The accuracy after post-filtering was lower compared to the unfiltered data with a mean (SD) RC of 0.63 (0.05) and 0.70 (0.07), respectively (p < 0.05). More artificial defects were found on Bull’s eye plots created with the unfiltered data compared to filtered data. Eight out of ten patients showed significant changes in uptake before and after treatment (p < 0.05).Conclusion: Quantification of 99mTc-tetrofosmin SPECT/CT seems feasible for CAD patients when 7 iterations (10 subsets), Butterworth post-filtering (cut off frequency 0.52 in cycles/cm, order of 5) and manual CT-delineation are applied. However, future prospective patient studies are required for clinical application.
AB - Background: Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction technique (Evolution; GE Healthcare) for the potential application of response monitoring using 99mTc-tetrofosmin SPECT/CT in patients with coronary artery disease (CAD).Methods: Acquisitions of an anthropomorphic torso phantom with cardiac insert containing defects (with varying sizes), filled with 99mTc-pertechnetate, were performed on a SPECT/CT (Discovery 670 Pro, GE Healthcare). Subsequently, volumes of interest of the defects were manually drawn on CT to assess the recovery coefficient (RC). Bull’s eye plots were composed to evaluate the uptake per segment. Finally, 99mTc-tetrofosmin SPECT/CT scans of 10 CAD patients were used to illustrate clinical application.Results: The phantom study indicated that Evolution showed convergence after 7 iterations and 10 subsets. The average repeatability deviation of all configurations was 2.91% and 3.15% (%SD mean) for filtered (Butterworth) and unfiltered data, respectively. The accuracy after post-filtering was lower compared to the unfiltered data with a mean (SD) RC of 0.63 (0.05) and 0.70 (0.07), respectively (p < 0.05). More artificial defects were found on Bull’s eye plots created with the unfiltered data compared to filtered data. Eight out of ten patients showed significant changes in uptake before and after treatment (p < 0.05).Conclusion: Quantification of 99mTc-tetrofosmin SPECT/CT seems feasible for CAD patients when 7 iterations (10 subsets), Butterworth post-filtering (cut off frequency 0.52 in cycles/cm, order of 5) and manual CT-delineation are applied. However, future prospective patient studies are required for clinical application.
KW - Tc-tetrofosmin
KW - Coronary artery disease
KW - Experimental validation
KW - Phantom study
KW - Quantitative SPECT
KW - SPECT/CT
UR - http://www.scopus.com/inward/record.url?scp=85108064923&partnerID=8YFLogxK
U2 - 10.1186/s40658-021-00393-4
DO - 10.1186/s40658-021-00393-4
M3 - Article
AN - SCOPUS:85108064923
SN - 2197-7364
VL - 8
JO - EJNMMI physics
JF - EJNMMI physics
IS - 1
M1 - 48
ER -
