Explaining burst profiles using models with realistic parameters and plastic synapses

T. Gritsun; J. Stegenga; Jakob le Feber; Wim Rutten

Explaining burst profiles using models with realistic parameters and plastic synapses

T. Gritsun, J. Stegenga, Jakob le Feber, Wim Rutten

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

45 Downloads (Pure)

Abstract

One of the most prominent features of the electrical activity of dissociated cultured neural networks is the phenomenon of network bursts. Profiles of the instantaneous firing rate during bursts vary in shape and intensity during neuronal culture development. To shed some light on burst profile variability we constructed “pacemaker-driven��? random recurrent neural network models with both static and frequency dependent synapses. We show variation of burst features by changing the network parameters of the models. The best agreement was found by including synapses with short-term plasticity.

Original language	Undefined
Title of host publication	6th International Meeting on Substrate-Integrated Microelectrodes
Place of Publication	Stuttgart, Germany
Publisher	BIOPRO Baden-Wuerttemberg GmbH
Pages	26-28
Number of pages	3
ISBN (Print)	3-938345-05-5
Publication status	Published - 8 Jul 2008
Event	6th international meeting on substrate-integrated micro electrode arrays 2008 - Stuttgart, Germany Duration: 8 Jul 2008 → 11 Jul 2008 Conference number: 6

Publication series

Name
Publisher	BIOPRO Baden-Wuerttemberg GmbH

Conference

Conference	6th international meeting on substrate-integrated micro electrode arrays 2008
Country/Territory	Germany
City	Stuttgart
Period	8/07/08 → 11/07/08

Keywords

METIS-265265
EWI-17282
IR-69663

Access to Document

Gritsun_mea_meeting_proceedings_2008

http://eprints.eemcs.utwente.nl/secure2/17282/01/Gritsun_mea_meeting_proceedings_2008.pdf

Cite this

@inproceedings{d1a76c7333cc401b968c993579130157,

title = "Explaining burst profiles using models with realistic parameters and plastic synapses",

abstract = "One of the most prominent features of the electrical activity of dissociated cultured neural networks is the phenomenon of network bursts. Profiles of the instantaneous firing rate during bursts vary in shape and intensity during neuronal culture development. To shed some light on burst profile variability we constructed “pacemaker-driven��? random recurrent neural network models with both static and frequency dependent synapses. We show variation of burst features by changing the network parameters of the models. The best agreement was found by including synapses with short-term plasticity.",

keywords = "METIS-265265, EWI-17282, IR-69663",

author = "T. Gritsun and J. Stegenga and {le Feber}, Jakob and Wim Rutten",

note = "http://www.nmi.de/meameeting2008/; 6th international meeting on substrate-integrated micro electrode arrays 2008 ; Conference date: 08-07-2008 Through 11-07-2008",

year = "2008",

month = jul,

day = "8",

language = "Undefined",

isbn = "3-938345-05-5",

publisher = "BIOPRO Baden-Wuerttemberg GmbH",

pages = "26--28",

booktitle = "6th International Meeting on Substrate-Integrated Microelectrodes",

}

Gritsun, T, Stegenga, J, le Feber, J & Rutten, W 2008, Explaining burst profiles using models with realistic parameters and plastic synapses. in 6th International Meeting on Substrate-Integrated Microelectrodes. BIOPRO Baden-Wuerttemberg GmbH, Stuttgart, Germany, pp. 26-28, 6th international meeting on substrate-integrated micro electrode arrays 2008, Stuttgart, Germany, 8/07/08. <http://eprints.eemcs.utwente.nl/secure2/17282/01/Gritsun_mea_meeting_proceedings_2008.pdf>

Explaining burst profiles using models with realistic parameters and plastic synapses. / Gritsun, T.; Stegenga, J.; le Feber, Jakob et al.
6th International Meeting on Substrate-Integrated Microelectrodes. Stuttgart, Germany: BIOPRO Baden-Wuerttemberg GmbH, 2008. p. 26-28.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - Explaining burst profiles using models with realistic parameters and plastic synapses

AU - Gritsun, T.

AU - Stegenga, J.

AU - le Feber, Jakob

AU - Rutten, Wim

N1 - Conference code: 6

PY - 2008/7/8

Y1 - 2008/7/8

N2 - One of the most prominent features of the electrical activity of dissociated cultured neural networks is the phenomenon of network bursts. Profiles of the instantaneous firing rate during bursts vary in shape and intensity during neuronal culture development. To shed some light on burst profile variability we constructed “pacemaker-driven��? random recurrent neural network models with both static and frequency dependent synapses. We show variation of burst features by changing the network parameters of the models. The best agreement was found by including synapses with short-term plasticity.

AB - One of the most prominent features of the electrical activity of dissociated cultured neural networks is the phenomenon of network bursts. Profiles of the instantaneous firing rate during bursts vary in shape and intensity during neuronal culture development. To shed some light on burst profile variability we constructed “pacemaker-driven��? random recurrent neural network models with both static and frequency dependent synapses. We show variation of burst features by changing the network parameters of the models. The best agreement was found by including synapses with short-term plasticity.

KW - METIS-265265

KW - EWI-17282

KW - IR-69663

M3 - Conference contribution

SN - 3-938345-05-5

SP - 26

EP - 28

BT - 6th International Meeting on Substrate-Integrated Microelectrodes

PB - BIOPRO Baden-Wuerttemberg GmbH

CY - Stuttgart, Germany

T2 - 6th international meeting on substrate-integrated micro electrode arrays 2008

Y2 - 8 July 2008 through 11 July 2008

ER -