Exploring determinants of life sciences spin-off creation: empirical evidence from the Netherlands

Marianne van der Steen, Roland Ortt, Victor Scholten

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This paper empirically explores the determinants that are important for the creation of science-based spin-offs. We propose a model in which human capital, technology-based and institutional determinants affect the spin-off creation process. The data are drawn from the BioPartner First Stage Grant, a seed fund to stimulate academic spin-offs in the Life Sciences. The unique data set covers 68 Life Sciences spin-off projects. This study explores the determinants of success of these spin-offs in three subsequent stages of the spin-off creation process and for the overall process. Empirical evidence shows that an externally attracted CEO positively influences the spin-off creation and leverages the effect of the spin-offs scientific quality. Furthermore, we find evidence for the role of product potential, IP position and industry experience which vary during the spin-off creation process. Finally, we discuss managerial and policy implications.
Original languageEnglish
Pages (from-to)30-48
JournalInternational journal of entrepreneurship and small business
Issue number1
Publication statusPublished - 2010


  • life sciences
  • spin-off creation
  • IR-101756
  • academic entrepreneurship
  • academic spin-offs
  • The Netherlands
  • METIS-267303


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