Extracellular Potentials from Active Myelinated Fibers Inside Insulated and Noninsulated Peripheral Nerve

J.H. Meier, Jan H. Meier, Wim Rutten, H.B.K. Boom

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    Abstract

    A model is presented that calculates the single-fiber extracellular field and action potential (ap) of an active myelinated nerve fiber placed centrally or eccentrically inside a nerve with a cylindrical geometry, representing essentially a one-fascicle nerve. This one-fascicle nerve has the dimensions and conductivities of the rat peroneal nerve branch. The results show a wide variety of wave shapes to be measured, depending on the position of the intraneural electrode with respect to the fiber axis and to the nodes of Ranvier and depending on the presence of an isolating cuff around the nerve. Action potential shapes may range from the ¿classical¿ quasi-biphasic one, to more triphasic, or even more complicated in the case of a short insulating cuff being present around the nerve. In the latter case, when measured bipolarly, ap-wave shapes become almost monophasic
    Original languageUndefined
    Pages (from-to)1146-1153
    Number of pages8
    JournalIEEE transactions on biomedical engineering
    Volume45
    Issue number9
    DOIs
    Publication statusPublished - 1998

    Keywords

    • METIS-112284
    • IR-15409

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