TY - JOUR
T1 - F1C fimbriae of a uropathogenic Escherichia coli strain
T2 - Genetic and functional organization of the foc gene cluster and identification of minor subunits
AU - Riegman, Nico
AU - Kusters, Ron
AU - Van Veggel, Hans
AU - Bergmans, Hans
AU - van Bergen en Henegouwen, Paul
AU - Hacker, Jörg
AU - van Die, Irma
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The genetic organization of the foc gene cluster has been studied; six genes involved in the biogenesis of F1C fimbriae were identified. focA encodes the major fimbrial subunit, focC encodes a product that is indispensable for fimbria formation, focG and focH encode fimbrial subunits, and focI encodes a protein which shows at least two minor subunits, FocG and FocH. Minor proteins of similar size were observed in purified S fimrbiae. Remarkably, some mutations in the foc gene cluster result in an altered fimbrial morphology, i.e., rigid stubs or long, curly fimbriae.
AB - The genetic organization of the foc gene cluster has been studied; six genes involved in the biogenesis of F1C fimbriae were identified. focA encodes the major fimbrial subunit, focC encodes a product that is indispensable for fimbria formation, focG and focH encode fimbrial subunits, and focI encodes a protein which shows at least two minor subunits, FocG and FocH. Minor proteins of similar size were observed in purified S fimrbiae. Remarkably, some mutations in the foc gene cluster result in an altered fimbrial morphology, i.e., rigid stubs or long, curly fimbriae.
UR - http://www.scopus.com/inward/record.url?scp=0025020690&partnerID=8YFLogxK
U2 - 10.1128/jb.172.2.1114-1120.1990
DO - 10.1128/jb.172.2.1114-1120.1990
M3 - Article
C2 - 1967600
AN - SCOPUS:0025020690
SN - 0021-9193
VL - 172
SP - 1114
EP - 1120
JO - Journal of Bacteriology
JF - Journal of Bacteriology
IS - 2
ER -