F1C fimbriae of a uropathogenic Escherichia coli strain: Genetic and functional organization of the foc gene cluster and identification of minor subunits

Nico Riegman, Ron Kusters, Hans Van Veggel, Hans Bergmans, Paul van Bergen en Henegouwen, Jörg Hacker, Irma van Die

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    Abstract

    The genetic organization of the foc gene cluster has been studied; six genes involved in the biogenesis of F1C fimbriae were identified. focA encodes the major fimbrial subunit, focC encodes a product that is indispensable for fimbria formation, focG and focH encode fimbrial subunits, and focI encodes a protein which shows at least two minor subunits, FocG and FocH. Minor proteins of similar size were observed in purified S fimrbiae. Remarkably, some mutations in the foc gene cluster result in an altered fimbrial morphology, i.e., rigid stubs or long, curly fimbriae.

    Original languageEnglish
    Pages (from-to)1114-1120
    Number of pages7
    JournalJournal of Bacteriology
    Volume172
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 1990

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    Uropathogenic Escherichia coli
    Multigene Family
    Proteins
    Mutation
    Genes

    Cite this

    Riegman, Nico ; Kusters, Ron ; Van Veggel, Hans ; Bergmans, Hans ; van Bergen en Henegouwen, Paul ; Hacker, Jörg ; van Die, Irma. / F1C fimbriae of a uropathogenic Escherichia coli strain : Genetic and functional organization of the foc gene cluster and identification of minor subunits. In: Journal of Bacteriology. 1990 ; Vol. 172, No. 2. pp. 1114-1120.
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    abstract = "The genetic organization of the foc gene cluster has been studied; six genes involved in the biogenesis of F1C fimbriae were identified. focA encodes the major fimbrial subunit, focC encodes a product that is indispensable for fimbria formation, focG and focH encode fimbrial subunits, and focI encodes a protein which shows at least two minor subunits, FocG and FocH. Minor proteins of similar size were observed in purified S fimrbiae. Remarkably, some mutations in the foc gene cluster result in an altered fimbrial morphology, i.e., rigid stubs or long, curly fimbriae.",
    author = "Nico Riegman and Ron Kusters and {Van Veggel}, Hans and Hans Bergmans and {van Bergen en Henegouwen}, Paul and J{\"o}rg Hacker and {van Die}, Irma",
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    F1C fimbriae of a uropathogenic Escherichia coli strain : Genetic and functional organization of the foc gene cluster and identification of minor subunits. / Riegman, Nico; Kusters, Ron; Van Veggel, Hans; Bergmans, Hans; van Bergen en Henegouwen, Paul; Hacker, Jörg; van Die, Irma.

    In: Journal of Bacteriology, Vol. 172, No. 2, 01.01.1990, p. 1114-1120.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Riegman, Nico

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