F1C fimbriae of a uropathogenic Escherichia coli strain: Genetic and functional organization of the foc gene cluster and identification of minor subunits

Nico Riegman, Ron Kusters, Hans Van Veggel, Hans Bergmans, Paul van Bergen en Henegouwen, Jörg Hacker, Irma van Die

    Research output: Contribution to journalArticleAcademicpeer-review

    39 Citations (Scopus)
    56 Downloads (Pure)

    Abstract

    The genetic organization of the foc gene cluster has been studied; six genes involved in the biogenesis of F1C fimbriae were identified. focA encodes the major fimbrial subunit, focC encodes a product that is indispensable for fimbria formation, focG and focH encode fimbrial subunits, and focI encodes a protein which shows at least two minor subunits, FocG and FocH. Minor proteins of similar size were observed in purified S fimrbiae. Remarkably, some mutations in the foc gene cluster result in an altered fimbrial morphology, i.e., rigid stubs or long, curly fimbriae.

    Original languageEnglish
    Pages (from-to)1114-1120
    Number of pages7
    JournalJournal of Bacteriology
    Volume172
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 1990

    Fingerprint Dive into the research topics of 'F1C fimbriae of a uropathogenic Escherichia coli strain: Genetic and functional organization of the foc gene cluster and identification of minor subunits'. Together they form a unique fingerprint.

    Cite this