Fabrication of nanofibrous scaffolds for tissue engineering applications

H. Chen, R.K. Truckenmüller, Clemens van Blitterswijk, Lorenzo Moroni

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

33 Citations (Scopus)
843 Downloads (Pure)


Nanofibrous scaffolds which mimic the structural features of a natural extracellular matrix (ECM) can be appealing scaffold candidates for tissue engineering as they provide similar physical cues to the native environment of the targeted tissue to regenerate. This chapter discusses different strategies to fabricate nanofibrous scaffolds for tissue engineering. We first describe three major methods for nanofibrous scaffold fabrication: molecular self-assembly, phase separation, and electrospinning. Then, approaches for surface modification of nanofibrous scaffolds including blending and coating, plasma treatment, wet chemical methods, and surface graft polymerization are presented. Finally, applications of nanofibrous scaffolds in tissue engineering are introduced.
Original languageEnglish
Title of host publicationNanomaterials in tissue engineering: Fabrication and applications
EditorsA.K. Gaharwar, S. Sant, M.J. Hancock, A.A. Hacking
PublisherWoodhead Publishing
Number of pages25
ISBN (Print)978-0-85709-596-1
Publication statusPublished - 2013

Publication series

NameSeries in Biomaterials
PublisherWoodhead Publishing


  • IR-88370
  • METIS-299735


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