Fabrication of patient specific composite orbital floor implants by stereolithography

Mike Alexander Geven, V. Varjas, L. Kamer, X. Wang, J. Peng, D. Eglin, Dirk W. Grijpma

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Fractures of the orbital floor are common in traffic accidents and assaults, and inadequate treatment can result in serious complications. Accurate anatomical reconstruction of the orbit using implants is the preferred treatment. Implants require degradability, adequate mechanical properties to support the orbital contents, and osteoinductivity or osteoconductivity so that the implant is replaced by de novo bone over time. Here, we report on a semi-automatic process for the generation of virtual models of patient-specific implants for orbital floor reconstruction. These models were generated using clinical computed tomography images of five clinical cases of orbital fracture. To fabricate accurately shaped implants based on the models, we utilized stereolithography, a high-resolution additive manufacturing technique. We prepared resins from bioresorbable, photo-curable functionalized poly(trimethylene carbonate) oligomers and osteoinductive nano-hydroxyapatite to manufacture composite implants. Incorporation of 40 wt.% nano-hydroxyapatite into photo-crosslinked poly(trimethylene carbonate) leads to an increase of the E modulus, ultimate strength and toughness from 2.8 to 60 MPa, 2.4 to 7.1 N/mm2 and 330 to 1671 N/mm2, respectively. Additionally, water uptake increased from 0.8% to 7.3%, and water contact angle decreased from 80° to 68°. Patient-specific, homogeneous, and mechanically stable implants can readily be prepared using these composite resins.
Original languageUndefined
Pages (from-to)1433-1438
JournalPolymers for advanced technologies
Volume26
Issue number12
DOIs
Publication statusPublished - 2015

Keywords

  • METIS-315295
  • IR-99962

Cite this

Geven, Mike Alexander ; Varjas, V. ; Kamer, L. ; Wang, X. ; Peng, J. ; Eglin, D. ; Grijpma, Dirk W. / Fabrication of patient specific composite orbital floor implants by stereolithography. In: Polymers for advanced technologies. 2015 ; Vol. 26, No. 12. pp. 1433-1438.
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abstract = "Fractures of the orbital floor are common in traffic accidents and assaults, and inadequate treatment can result in serious complications. Accurate anatomical reconstruction of the orbit using implants is the preferred treatment. Implants require degradability, adequate mechanical properties to support the orbital contents, and osteoinductivity or osteoconductivity so that the implant is replaced by de novo bone over time. Here, we report on a semi-automatic process for the generation of virtual models of patient-specific implants for orbital floor reconstruction. These models were generated using clinical computed tomography images of five clinical cases of orbital fracture. To fabricate accurately shaped implants based on the models, we utilized stereolithography, a high-resolution additive manufacturing technique. We prepared resins from bioresorbable, photo-curable functionalized poly(trimethylene carbonate) oligomers and osteoinductive nano-hydroxyapatite to manufacture composite implants. Incorporation of 40 wt.{\%} nano-hydroxyapatite into photo-crosslinked poly(trimethylene carbonate) leads to an increase of the E modulus, ultimate strength and toughness from 2.8 to 60 MPa, 2.4 to 7.1 N/mm2 and 330 to 1671 N/mm2, respectively. Additionally, water uptake increased from 0.8{\%} to 7.3{\%}, and water contact angle decreased from 80° to 68°. Patient-specific, homogeneous, and mechanically stable implants can readily be prepared using these composite resins.",
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Fabrication of patient specific composite orbital floor implants by stereolithography. / Geven, Mike Alexander; Varjas, V.; Kamer, L.; Wang, X.; Peng, J.; Eglin, D.; Grijpma, Dirk W.

In: Polymers for advanced technologies, Vol. 26, No. 12, 2015, p. 1433-1438.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Fabrication of patient specific composite orbital floor implants by stereolithography

AU - Geven, Mike Alexander

AU - Varjas, V.

AU - Kamer, L.

AU - Wang, X.

AU - Peng, J.

AU - Eglin, D.

AU - Grijpma, Dirk W.

N1 - Special Issue: Advanced functional polymers for medicine

PY - 2015

Y1 - 2015

N2 - Fractures of the orbital floor are common in traffic accidents and assaults, and inadequate treatment can result in serious complications. Accurate anatomical reconstruction of the orbit using implants is the preferred treatment. Implants require degradability, adequate mechanical properties to support the orbital contents, and osteoinductivity or osteoconductivity so that the implant is replaced by de novo bone over time. Here, we report on a semi-automatic process for the generation of virtual models of patient-specific implants for orbital floor reconstruction. These models were generated using clinical computed tomography images of five clinical cases of orbital fracture. To fabricate accurately shaped implants based on the models, we utilized stereolithography, a high-resolution additive manufacturing technique. We prepared resins from bioresorbable, photo-curable functionalized poly(trimethylene carbonate) oligomers and osteoinductive nano-hydroxyapatite to manufacture composite implants. Incorporation of 40 wt.% nano-hydroxyapatite into photo-crosslinked poly(trimethylene carbonate) leads to an increase of the E modulus, ultimate strength and toughness from 2.8 to 60 MPa, 2.4 to 7.1 N/mm2 and 330 to 1671 N/mm2, respectively. Additionally, water uptake increased from 0.8% to 7.3%, and water contact angle decreased from 80° to 68°. Patient-specific, homogeneous, and mechanically stable implants can readily be prepared using these composite resins.

AB - Fractures of the orbital floor are common in traffic accidents and assaults, and inadequate treatment can result in serious complications. Accurate anatomical reconstruction of the orbit using implants is the preferred treatment. Implants require degradability, adequate mechanical properties to support the orbital contents, and osteoinductivity or osteoconductivity so that the implant is replaced by de novo bone over time. Here, we report on a semi-automatic process for the generation of virtual models of patient-specific implants for orbital floor reconstruction. These models were generated using clinical computed tomography images of five clinical cases of orbital fracture. To fabricate accurately shaped implants based on the models, we utilized stereolithography, a high-resolution additive manufacturing technique. We prepared resins from bioresorbable, photo-curable functionalized poly(trimethylene carbonate) oligomers and osteoinductive nano-hydroxyapatite to manufacture composite implants. Incorporation of 40 wt.% nano-hydroxyapatite into photo-crosslinked poly(trimethylene carbonate) leads to an increase of the E modulus, ultimate strength and toughness from 2.8 to 60 MPa, 2.4 to 7.1 N/mm2 and 330 to 1671 N/mm2, respectively. Additionally, water uptake increased from 0.8% to 7.3%, and water contact angle decreased from 80° to 68°. Patient-specific, homogeneous, and mechanically stable implants can readily be prepared using these composite resins.

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