Facile method of building hydroxyapatite 3D scaffolds assembled from porous hollow fibers enabling nutrient delivery

David Salamon, Sandra Da Silva Teixeira, S.M. Dutczak, Dimitrios Stamatialis

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Nowadays, diffusion through scaffold and tissue usually limits transport, and forms potentially hypoxic regions. Several methods are used for preparation of 3D hydroxyapatite scaffolds, however, production of a scaffold including porous hollow fibers for nutrition delivery is difficult and expensive. In this study, we describe an easy and inexpensive method to create 3D hydroxyapatite structure containing porous hollow fibers via microtemplating. The fibers which are assembled into 3D scaffold and sintered, contain asymmetric membrane walls with flux suitable for nutrient delivery. These hollow fibers have good mesenchymal stem cell adhesion showing that the presented method has no negative influence on cell cytocompatibility. The proposed straightforward method for building 3D structures containing porous hollow fibers for nutritions can be suitable for in vitro bioreactors studies as well as for production tissue engineered or in vivo prepared bone grafts
Original languageEnglish
Pages (from-to)14793-14799
JournalCeramics international
Volume40
Issue number9, Part B
DOIs
Publication statusPublished - 2014

Keywords

  • IR-92728
  • METIS-306587

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