Facile method of building hydroxyapatite 3D scaffolds assembled from porous hollow fibers enabling nutrient delivery

David Salamon, Sandra Da Silva Teixeira, S.M. Dutczak, Dimitrios Stamatialis

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Nowadays, diffusion through scaffold and tissue usually limits transport, and forms potentially hypoxic regions. Several methods are used for preparation of 3D hydroxyapatite scaffolds, however, production of a scaffold including porous hollow fibers for nutrition delivery is difficult and expensive. In this study, we describe an easy and inexpensive method to create 3D hydroxyapatite structure containing porous hollow fibers via microtemplating. The fibers which are assembled into 3D scaffold and sintered, contain asymmetric membrane walls with flux suitable for nutrient delivery. These hollow fibers have good mesenchymal stem cell adhesion showing that the presented method has no negative influence on cell cytocompatibility. The proposed straightforward method for building 3D structures containing porous hollow fibers for nutritions can be suitable for in vitro bioreactors studies as well as for production tissue engineered or in vivo prepared bone grafts
Original languageEnglish
Pages (from-to)14793-14799
JournalCeramics international
Volume40
Issue number9, Part B
DOIs
Publication statusPublished - 2014

Fingerprint

Scaffolds (biology)
Hydroxyapatite
Nutrients
Scaffolds
Fibers
Nutrition
Tissue
Forms (concrete)
Cell adhesion
Bioreactors
Stem cells
Grafts
Bone
Fluxes
Membranes

Keywords

  • IR-92728
  • METIS-306587

Cite this

Salamon, David ; Da Silva Teixeira, Sandra ; Dutczak, S.M. ; Stamatialis, Dimitrios. / Facile method of building hydroxyapatite 3D scaffolds assembled from porous hollow fibers enabling nutrient delivery. In: Ceramics international. 2014 ; Vol. 40, No. 9, Part B. pp. 14793-14799.
@article{57781abd862343e2b9a74be878d357cf,
title = "Facile method of building hydroxyapatite 3D scaffolds assembled from porous hollow fibers enabling nutrient delivery",
abstract = "Nowadays, diffusion through scaffold and tissue usually limits transport, and forms potentially hypoxic regions. Several methods are used for preparation of 3D hydroxyapatite scaffolds, however, production of a scaffold including porous hollow fibers for nutrition delivery is difficult and expensive. In this study, we describe an easy and inexpensive method to create 3D hydroxyapatite structure containing porous hollow fibers via microtemplating. The fibers which are assembled into 3D scaffold and sintered, contain asymmetric membrane walls with flux suitable for nutrient delivery. These hollow fibers have good mesenchymal stem cell adhesion showing that the presented method has no negative influence on cell cytocompatibility. The proposed straightforward method for building 3D structures containing porous hollow fibers for nutritions can be suitable for in vitro bioreactors studies as well as for production tissue engineered or in vivo prepared bone grafts",
keywords = "IR-92728, METIS-306587",
author = "David Salamon and {Da Silva Teixeira}, Sandra and S.M. Dutczak and Dimitrios Stamatialis",
year = "2014",
doi = "10.1016/j.ceramint.2014.06.071",
language = "English",
volume = "40",
pages = "14793--14799",
journal = "Ceramics international",
issn = "0272-8842",
publisher = "Elsevier",
number = "9, Part B",

}

Facile method of building hydroxyapatite 3D scaffolds assembled from porous hollow fibers enabling nutrient delivery. / Salamon, David; Da Silva Teixeira, Sandra; Dutczak, S.M.; Stamatialis, Dimitrios.

In: Ceramics international, Vol. 40, No. 9, Part B, 2014, p. 14793-14799.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Facile method of building hydroxyapatite 3D scaffolds assembled from porous hollow fibers enabling nutrient delivery

AU - Salamon, David

AU - Da Silva Teixeira, Sandra

AU - Dutczak, S.M.

AU - Stamatialis, Dimitrios

PY - 2014

Y1 - 2014

N2 - Nowadays, diffusion through scaffold and tissue usually limits transport, and forms potentially hypoxic regions. Several methods are used for preparation of 3D hydroxyapatite scaffolds, however, production of a scaffold including porous hollow fibers for nutrition delivery is difficult and expensive. In this study, we describe an easy and inexpensive method to create 3D hydroxyapatite structure containing porous hollow fibers via microtemplating. The fibers which are assembled into 3D scaffold and sintered, contain asymmetric membrane walls with flux suitable for nutrient delivery. These hollow fibers have good mesenchymal stem cell adhesion showing that the presented method has no negative influence on cell cytocompatibility. The proposed straightforward method for building 3D structures containing porous hollow fibers for nutritions can be suitable for in vitro bioreactors studies as well as for production tissue engineered or in vivo prepared bone grafts

AB - Nowadays, diffusion through scaffold and tissue usually limits transport, and forms potentially hypoxic regions. Several methods are used for preparation of 3D hydroxyapatite scaffolds, however, production of a scaffold including porous hollow fibers for nutrition delivery is difficult and expensive. In this study, we describe an easy and inexpensive method to create 3D hydroxyapatite structure containing porous hollow fibers via microtemplating. The fibers which are assembled into 3D scaffold and sintered, contain asymmetric membrane walls with flux suitable for nutrient delivery. These hollow fibers have good mesenchymal stem cell adhesion showing that the presented method has no negative influence on cell cytocompatibility. The proposed straightforward method for building 3D structures containing porous hollow fibers for nutritions can be suitable for in vitro bioreactors studies as well as for production tissue engineered or in vivo prepared bone grafts

KW - IR-92728

KW - METIS-306587

U2 - 10.1016/j.ceramint.2014.06.071

DO - 10.1016/j.ceramint.2014.06.071

M3 - Article

VL - 40

SP - 14793

EP - 14799

JO - Ceramics international

JF - Ceramics international

SN - 0272-8842

IS - 9, Part B

ER -