TY - JOUR
T1 - Facile template preparation of novel electroactive scaffold composed of polypyrrole-coated poly(glycerol-sebacate-urethane) for tissue engineering applications
AU - Golbaten-Mofrad, Hooman
AU - Seyfi Sahzabi, Alireza
AU - Seyfikar, Saba
AU - Salehi, Mohammad Hadi
AU - Goodarzi, Vahabodin
AU - Wurm, Frederik R.
AU - Jafari, Seyed Hassan
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/10/5
Y1 - 2021/10/5
N2 - Poly(glycerol-sebacate-urethane) (PGS-U) is an attractive candidate as a super-elastic and biocompatible scaffold for inserting nanoparticles and polymers with a straightforward synthesis. Herein, a series of PGS-U scaffolds with various crosslink densities was prepared for subsequent polypyrrole (PPy) polymerization. The in-situ polymerization of PPy was employed to deposit the PPy particles throughout the scaffolds, and the continuous electrically conductive pathways were built within the scaffolds. Moreover, due to their favorable mechanical and anti-bacterial properties, zinc oxide (ZnO) nanoparticles were embedded within the scaffold. The composition of the scaffolds was confirmed by different characterization techniques, including FTIR, FE-SEM, and EDX. Static and cyclic compression tests were conducted to evaluate the mechanical performance of scaffolds under dry and hydrated conditions. All scaffolds presented high structural stability and full shape recovery after releasing the load. They were thermally stable up to at least 200 °C. The addition of PPy boosted the electrical conductivity, and the inclusion of ZnO particles improved the surface hydrophilicity and anti-bacterial behavior of the scaffolds. Altogether, this study suggests the further developments of these nanocomposites as satisfactory electrically conductive scaffolds for tissue engineering applications.
AB - Poly(glycerol-sebacate-urethane) (PGS-U) is an attractive candidate as a super-elastic and biocompatible scaffold for inserting nanoparticles and polymers with a straightforward synthesis. Herein, a series of PGS-U scaffolds with various crosslink densities was prepared for subsequent polypyrrole (PPy) polymerization. The in-situ polymerization of PPy was employed to deposit the PPy particles throughout the scaffolds, and the continuous electrically conductive pathways were built within the scaffolds. Moreover, due to their favorable mechanical and anti-bacterial properties, zinc oxide (ZnO) nanoparticles were embedded within the scaffold. The composition of the scaffolds was confirmed by different characterization techniques, including FTIR, FE-SEM, and EDX. Static and cyclic compression tests were conducted to evaluate the mechanical performance of scaffolds under dry and hydrated conditions. All scaffolds presented high structural stability and full shape recovery after releasing the load. They were thermally stable up to at least 200 °C. The addition of PPy boosted the electrical conductivity, and the inclusion of ZnO particles improved the surface hydrophilicity and anti-bacterial behavior of the scaffolds. Altogether, this study suggests the further developments of these nanocomposites as satisfactory electrically conductive scaffolds for tissue engineering applications.
KW - 2022 OA procedure
KW - In-situ Polymerization
KW - Poly(glycerol sebacate urethane)
KW - Polypyrrole
KW - Zinc-Oxide
KW - Elastic Scaffold
UR - http://www.scopus.com/inward/record.url?scp=85118767429&partnerID=8YFLogxK
U2 - 10.1016/j.eurpolymj.2021.110749
DO - 10.1016/j.eurpolymj.2021.110749
M3 - Article
AN - SCOPUS:85118767429
SN - 0014-3057
VL - 159
JO - European polymer journal
JF - European polymer journal
M1 - 110749
ER -