Facile template preparation of novel electroactive scaffold composed of polypyrrole-coated poly(glycerol-sebacate-urethane) for tissue engineering applications

Hooman Golbaten-Mofrad, Alireza Seyfi Sahzabi, Saba Seyfikar, Mohammad Hadi Salehi, Vahabodin Goodarzi*, Frederik R. Wurm, Seyed Hassan Jafari

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)
163 Downloads (Pure)

Abstract

Poly(glycerol-sebacate-urethane) (PGS-U) is an attractive candidate as a super-elastic and biocompatible scaffold for inserting nanoparticles and polymers with a straightforward synthesis. Herein, a series of PGS-U scaffolds with various crosslink densities was prepared for subsequent polypyrrole (PPy) polymerization. The in-situ polymerization of PPy was employed to deposit the PPy particles throughout the scaffolds, and the continuous electrically conductive pathways were built within the scaffolds. Moreover, due to their favorable mechanical and anti-bacterial properties, zinc oxide (ZnO) nanoparticles were embedded within the scaffold. The composition of the scaffolds was confirmed by different characterization techniques, including FTIR, FE-SEM, and EDX. Static and cyclic compression tests were conducted to evaluate the mechanical performance of scaffolds under dry and hydrated conditions. All scaffolds presented high structural stability and full shape recovery after releasing the load. They were thermally stable up to at least 200 °C. The addition of PPy boosted the electrical conductivity, and the inclusion of ZnO particles improved the surface hydrophilicity and anti-bacterial behavior of the scaffolds. Altogether, this study suggests the further developments of these nanocomposites as satisfactory electrically conductive scaffolds for tissue engineering applications.

Original languageEnglish
Article number110749
JournalEuropean polymer journal
Volume159
Early online date2 Sept 2021
DOIs
Publication statusPublished - 5 Oct 2021

Keywords

  • Elastic Scaffold
  • In-situ Polymerization
  • Poly(glycerol sebacate urethane)
  • Polypyrrole
  • Zinc-Oxide

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