TY - JOUR
T1 - Facilitating implementation of organs-on-chips by open platform technology
AU - Vollertsen, Anke R.
AU - Vivas, Aisen
AU - van Meer, Berend
AU - van den Berg, Albert
AU - Odijk, Mathieu
AU - van der Meer, Andries D.
N1 - Funding Information:
This work was supported by the European Research Council (ERC) Advanced Grant “VESCEL” to A. van den Berg (Grant No. 669768), the ERC Proof of Concept Grant to A. van den Berg under Grant No. 897025, and by the Netherlands Organ-on-Chip Initiative, an NWO Gravitation Project (No. 024.003.001) funded by the Ministry of Education, Culture and Science of the government of the Netherlands.
Publisher Copyright:
© 2021 Author(s).
Financial transaction number:
342153884
PY - 2021/10/15
Y1 - 2021/10/15
N2 - Organ-on-chip (OoC) and multi-organs-on-chip (MOoC) systems have the potential to play an important role in drug discovery, disease modeling, and personalized medicine. However, most devices developed in academic labs remain at a proof-of-concept level and do not yet offer the ease-of-use, manufacturability, and throughput that are needed for widespread application. Commercially available OoC are easier to use but often lack the level of complexity of the latest devices in academia. Furthermore, researchers who want to combine different chips into MOoC systems are limited to one supplier, since commercial systems are not compatible with each other. Given these limitations, the implementation of standards in the design and operation of OoCs would strongly facilitate their acceptance by users. Importantly, the implementation of such standards must be carried out by many participants from both industry and academia to ensure a widespread acceptance and adoption. This means that standards must also leave room for proprietary technology development next to promoting interchangeability. An open platform with standardized interfacing and user-friendly operation can fulfill these requirements. In this Perspective article, the concept of an open platform for OoCs is defined from a technical perspective. Moreover, we discuss the importance of involving different stakeholders in the development, manufacturing, and application of such an open platform.
AB - Organ-on-chip (OoC) and multi-organs-on-chip (MOoC) systems have the potential to play an important role in drug discovery, disease modeling, and personalized medicine. However, most devices developed in academic labs remain at a proof-of-concept level and do not yet offer the ease-of-use, manufacturability, and throughput that are needed for widespread application. Commercially available OoC are easier to use but often lack the level of complexity of the latest devices in academia. Furthermore, researchers who want to combine different chips into MOoC systems are limited to one supplier, since commercial systems are not compatible with each other. Given these limitations, the implementation of standards in the design and operation of OoCs would strongly facilitate their acceptance by users. Importantly, the implementation of such standards must be carried out by many participants from both industry and academia to ensure a widespread acceptance and adoption. This means that standards must also leave room for proprietary technology development next to promoting interchangeability. An open platform with standardized interfacing and user-friendly operation can fulfill these requirements. In this Perspective article, the concept of an open platform for OoCs is defined from a technical perspective. Moreover, we discuss the importance of involving different stakeholders in the development, manufacturing, and application of such an open platform.
UR - http://www.scopus.com/inward/record.url?scp=85117091325&partnerID=8YFLogxK
U2 - 10.1063/5.0063428
DO - 10.1063/5.0063428
M3 - Review article
AN - SCOPUS:85117091325
SN - 1932-1058
VL - 15
JO - Biomicrofluidics
JF - Biomicrofluidics
IS - 5
M1 - 051301
ER -
