Abstract
Objective: To evaluate whether the P50 gating deficit is present in young first-episode patients with schizophrenia and their healthy young siblings. Methods: An auditory paired-click paradigm was used to assess P50 gating in 53 patients, 27 unaffected siblings, and 28 healthy controls. P50 parameters were compared between patients, sibs, and unrelated controls by a mixed-effects regression model. Results: P50 gating was not significantly impaired in patients with schizophrenia and healthy siblings as compared with controls. Conclusions: P50 gating was not found to be significantly impaired in young first-episode schizophrenia patients and in healthy young siblings. These results are in contrast with the existing literature. We suggest that P50 gating impairment may be developmentally or age dependent.
Original language | English |
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Pages (from-to) | 1319-1323 |
Number of pages | 5 |
Journal | Schizophrenia Bulletin |
Volume | 33 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Nov 2007 |
Externally published | Yes |
Keywords
- Early psychosis
- Endophenotype
- Neurophysiology
- Relatives