Failure to find P50 suppression deficits in young first-episode patients with schizophrenia and clinically unaffected siblings

O.M. de Wilde*, L.J. Bour, P.M. Dingemans, J.H.T.M. Koelman, D.H. Linszen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Abstract

Objective: To evaluate whether the P50 gating deficit is present in young first-episode patients with schizophrenia and their healthy young siblings. Methods: An auditory paired-click paradigm was used to assess P50 gating in 53 patients, 27 unaffected siblings, and 28 healthy controls. P50 parameters were compared between patients, sibs, and unrelated controls by a mixed-effects regression model. Results: P50 gating was not significantly impaired in patients with schizophrenia and healthy siblings as compared with controls. Conclusions: P50 gating was not found to be significantly impaired in young first-episode schizophrenia patients and in healthy young siblings. These results are in contrast with the existing literature. We suggest that P50 gating impairment may be developmentally or age dependent.

Original languageEnglish
Pages (from-to)1319-1323
Number of pages5
JournalSchizophrenia Bulletin
Volume33
Issue number6
DOIs
Publication statusPublished - 1 Nov 2007
Externally publishedYes

Keywords

  • Early psychosis
  • Endophenotype
  • Neurophysiology
  • Relatives

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