Fast interactive elastic registration of 12-bit multi-spectral images with subvoxel accuracy using display hardware

Herke Jan Noordmans*, Rowland De Roode, Rudolf Verdaasdonk

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)
8 Downloads (Pure)


Multi-spectral images of human tissue taken in-vivo often contain image alignment problems as patients have difficulty in retaining their posture during the acquisition time of 20 seconds. Previously, it has been attempted to correct motion errors with image registration software developed for MR or CT data but these algorithms have been proven to be too slow and erroneous for practical use with multi-spectral images. A new software package has been developed which allows the user to play a decisive role in the registration process as the user can monitor the progress of the registration continuously and force it in the right direction when it starts to fail. The software efficiently exploits videocard hardware to gain speed and to provide a perfect subvoxel correspondence between registration field and display. An 8 bit graphic card was used to efficiently register and resample 12 bit images using the hardware interpolation modes present on the graphic card. To show the feasibility of this new registration process, the software was applied in clinical practice evaluating the dosimetry for psoriasis and KTP laser treatment. The microscopic differences between images of normal skin and skin exposed to UV light proved that an affine registration step including zooming and slanting is critical for a subsequent elastic match to have success. The combination of user interactive registration software with optimal addressing the potentials of PC video card hardware greatly improves the speed of multi spectral image registration.

Original languageEnglish
Title of host publicationMedical Imaging 2007
Subtitle of host publicationImage Processing
EditionPART 2
Publication statusPublished - 23 Nov 2007
Externally publishedYes
EventMedical Imaging 2007: Image Processing - San Diego, United States
Duration: 18 Feb 200720 Feb 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 2
ISSN (Print)1605-7422


ConferenceMedical Imaging 2007: Image Processing
Country/TerritoryUnited States
CitySan Diego


  • Clinical evaluation over time
  • Dermatology
  • Image registration
  • Multi-spectral imaging


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