Fast liquid chromatography/electrochemistry/mass spectrometry of ferrocenecarboxylic acid esters

J.G.R. Diehl, U. Karst

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Rapid liquid chromatographic separations of ferrocenecarboxylic esters of various alcohols and phenols have been achieved on reversed-phase columns of 20 mm length. After separation, the ferrocene derivatives are oxidized electrochemically under formation of the charged ferrocinium species, which are easily detected by mass spectrometry using an atmospheric pressure chemical ionization source operated in the heated nebulizer mode. While a series of nine phenol derivatives was separated within less than 1.5 min, six alcohol derivatives eluted within 1 min. Limits of detection using a single quadrupole mass analyzer ranged from 60 to 190 nmol/l. Additional work was directed on the use of a graphite in-line filter instead of a silica-based reversed-phase column to achieve the separation.
Original languageUndefined
Pages (from-to)103-109
JournalJournal of chromatography A
Volume974
Issue number1-2
DOIs
Publication statusPublished - 2002

Keywords

  • IR-38114
  • METIS-208821

Cite this

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abstract = "Rapid liquid chromatographic separations of ferrocenecarboxylic esters of various alcohols and phenols have been achieved on reversed-phase columns of 20 mm length. After separation, the ferrocene derivatives are oxidized electrochemically under formation of the charged ferrocinium species, which are easily detected by mass spectrometry using an atmospheric pressure chemical ionization source operated in the heated nebulizer mode. While a series of nine phenol derivatives was separated within less than 1.5 min, six alcohol derivatives eluted within 1 min. Limits of detection using a single quadrupole mass analyzer ranged from 60 to 190 nmol/l. Additional work was directed on the use of a graphite in-line filter instead of a silica-based reversed-phase column to achieve the separation.",
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author = "J.G.R. Diehl and U. Karst",
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Fast liquid chromatography/electrochemistry/mass spectrometry of ferrocenecarboxylic acid esters. / Diehl, J.G.R.; Karst, U.

In: Journal of chromatography A, Vol. 974, No. 1-2, 2002, p. 103-109.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Fast liquid chromatography/electrochemistry/mass spectrometry of ferrocenecarboxylic acid esters

AU - Diehl, J.G.R.

AU - Karst, U.

PY - 2002

Y1 - 2002

N2 - Rapid liquid chromatographic separations of ferrocenecarboxylic esters of various alcohols and phenols have been achieved on reversed-phase columns of 20 mm length. After separation, the ferrocene derivatives are oxidized electrochemically under formation of the charged ferrocinium species, which are easily detected by mass spectrometry using an atmospheric pressure chemical ionization source operated in the heated nebulizer mode. While a series of nine phenol derivatives was separated within less than 1.5 min, six alcohol derivatives eluted within 1 min. Limits of detection using a single quadrupole mass analyzer ranged from 60 to 190 nmol/l. Additional work was directed on the use of a graphite in-line filter instead of a silica-based reversed-phase column to achieve the separation.

AB - Rapid liquid chromatographic separations of ferrocenecarboxylic esters of various alcohols and phenols have been achieved on reversed-phase columns of 20 mm length. After separation, the ferrocene derivatives are oxidized electrochemically under formation of the charged ferrocinium species, which are easily detected by mass spectrometry using an atmospheric pressure chemical ionization source operated in the heated nebulizer mode. While a series of nine phenol derivatives was separated within less than 1.5 min, six alcohol derivatives eluted within 1 min. Limits of detection using a single quadrupole mass analyzer ranged from 60 to 190 nmol/l. Additional work was directed on the use of a graphite in-line filter instead of a silica-based reversed-phase column to achieve the separation.

KW - IR-38114

KW - METIS-208821

U2 - 10.1016/S0021-9673(02)01310-9

DO - 10.1016/S0021-9673(02)01310-9

M3 - Article

VL - 974

SP - 103

EP - 109

JO - Journal of chromatography A

JF - Journal of chromatography A

SN - 0021-9673

IS - 1-2

ER -