Feasibility of evanescent wave interferometer immunosensors for pesticide detection: chemical aspects

L.M. Lechuga, A.T.M. Lenferink, R.P.H. Kooyman, J. Greve

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)
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Abstract

A waveguide Mach-Zehnder Interferometer (MZI) immunosensor has been developed which can detect, in a direct way, a minimum average layer growth thickness of the analyte of 2×10−3 nm (bound mass, I′=1×10−4 δ cm−2). The design and fabrication of the sensor and the experimental set-up are aimed at decreasing the detection limit. A flow cell has been designed and incorporated into the set-up to allow a high mass-transport rate of the analyte molecules to the sensor surface, in this way decreasing the net response time. Results for the immunosystem α-hSA/hSA are presented. All improvements have been done as a first step towards the use of the MZI immunosensor in the direct detection of low coverages of pesticides with an expected layer growth of 2×10−4 nm.
Original languageEnglish
Pages (from-to)762-765
Number of pages4
JournalSensors and actuators. B: Chemical
Volume25
Issue number24-25
DOIs
Publication statusPublished - 1995

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