TY - JOUR
T1 - Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system
AU - van den Berg, Pim J.
AU - Daoudi, Khalid
AU - Bernelot Moens, Hein J.
AU - Steenbergen, Wiendelt
PY - 2017/12/1
Y1 - 2017/12/1
N2 - We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0.001 for both). US-PD and PAI were strongly correlated (Spearman's ρ = 0.64, with 95% CI: 0.42, 0.79). Hence, PAI using a compact handheld probe is capable of detecting clinically evident synovitis. This motivates further investigation into the predictive value of PAI, including multispectral PAI, with other established modalities such as US-PD or MRI.
AB - We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0.001 for both). US-PD and PAI were strongly correlated (Spearman's ρ = 0.64, with 95% CI: 0.42, 0.79). Hence, PAI using a compact handheld probe is capable of detecting clinically evident synovitis. This motivates further investigation into the predictive value of PAI, including multispectral PAI, with other established modalities such as US-PD or MRI.
KW - Echography
KW - Feasibility study
KW - Medical ultrasound
KW - Optoacoustic
KW - Photoacoustic
KW - Proof of principle
KW - Rheumatoid arthritis
KW - Synovitis
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=85028708533&partnerID=8YFLogxK
U2 - 10.1016/j.pacs.2017.08.002
DO - 10.1016/j.pacs.2017.08.002
M3 - Article
AN - SCOPUS:85028708533
VL - 8
SP - 8
EP - 14
JO - Photoacoustics
JF - Photoacoustics
SN - 2213-5979
ER -