Abstract
We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0.001 for both). US-PD and PAI were strongly correlated (Spearman's ρ = 0.64, with 95% CI: 0.42, 0.79). Hence, PAI using a compact handheld probe is capable of detecting clinically evident synovitis. This motivates further investigation into the predictive value of PAI, including multispectral PAI, with other established modalities such as US-PD or MRI.
| Original language | English |
|---|---|
| Pages (from-to) | 8-14 |
| Number of pages | 7 |
| Journal | Photoacoustics |
| Volume | 8 |
| DOIs | |
| Publication status | Published - 1 Dec 2017 |
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Keywords
- Echography
- Feasibility study
- Medical ultrasound
- Optoacoustic
- Photoacoustic
- Proof of principle
- Rheumatoid arthritis
- Synovitis
- Ultrasonography
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Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system. / van den Berg, Pim J.; Daoudi, Khalid; Bernelot Moens, Hein J.; Steenbergen, Wiendelt.
In: Photoacoustics, Vol. 8, 01.12.2017, p. 8-14.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system
AU - van den Berg, Pim J.
AU - Daoudi, Khalid
AU - Bernelot Moens, Hein J.
AU - Steenbergen, Wiendelt
PY - 2017/12/1
Y1 - 2017/12/1
N2 - We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0.001 for both). US-PD and PAI were strongly correlated (Spearman's ρ = 0.64, with 95% CI: 0.42, 0.79). Hence, PAI using a compact handheld probe is capable of detecting clinically evident synovitis. This motivates further investigation into the predictive value of PAI, including multispectral PAI, with other established modalities such as US-PD or MRI.
AB - We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0.001 for both). US-PD and PAI were strongly correlated (Spearman's ρ = 0.64, with 95% CI: 0.42, 0.79). Hence, PAI using a compact handheld probe is capable of detecting clinically evident synovitis. This motivates further investigation into the predictive value of PAI, including multispectral PAI, with other established modalities such as US-PD or MRI.
KW - Echography
KW - Feasibility study
KW - Medical ultrasound
KW - Optoacoustic
KW - Photoacoustic
KW - Proof of principle
KW - Rheumatoid arthritis
KW - Synovitis
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=85028708533&partnerID=8YFLogxK
U2 - 10.1016/j.pacs.2017.08.002
DO - 10.1016/j.pacs.2017.08.002
M3 - Article
VL - 8
SP - 8
EP - 14
JO - Photoacoustics
JF - Photoacoustics
SN - 2213-5979
ER -