Femtosecond laser written waveguides for fluorescence-sensing during microchip capillary electrophoresis

C. Dongre, R. Dekker, Hugo Hoekstra, D. Nolli, R. Martinez-Vazquez, R. Osellame, P. Laporta, G. Cerullo, G.A.J. Besselink, R. van Weeghel, Markus Pollnau

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    Abstract

    The substitution of conventional bench-top instrumentation by fully integrated lab-on-chip systems continues to be a challenge. The integration of microfluidics and integrated optics in glass is an important step towards this goal, forming the focus of this work [1]. In particular, excitation and detection of fluorescence emitted by labeled biomolecules flowing through a microfluidic channel is considered. Excitation occurs at specific wavelengths by means of waveguides inscribed with femtosecond laser pulses in a commercial, glass lab-on-chip. A widely known diagnostic application that will exploit this sensing scheme is the monitoring of microchip capillary electrophoresis (MCE) leading to separation of DNA fragments of different lengths, labeled with fluorescent dye molecules. In order to meet the resolution demands of MCE separation and to achieve multi-point sensing, we envision a device consisting of on-chip integrated optical splitters written coplanar with the microfluidic channel along which MCE separation takes place.
    Original languageUndefined
    Title of host publicationBook of Abstracts 9th European Conference on Optical Chemical Sensors and Biosensors (Europtrode IX)
    EditorsB. McCraith, C. McDonagh
    Place of PublicationDublin, Ireland
    PublisherDublin City University
    Pages116-117
    Number of pages2
    ISBN (Print)not assigned
    Publication statusPublished - Apr 2008
    Event9th European Conference on Optical Chemical Sensors and Biosensors, Europt(r)ode 2008 - Crowne Plaza Conference Centre, Dublin, Ireland
    Duration: 30 Mar 20082 Apr 2008
    Conference number: 9

    Publication series

    Name
    PublisherDublin City University
    Number302

    Conference

    Conference9th European Conference on Optical Chemical Sensors and Biosensors, Europt(r)ode 2008
    Abbreviated titleEuropt(r)ode 2008
    CountryIreland
    CityDublin
    Period30/03/082/04/08

    Keywords

    • EWI-12930
    • IOMS-SNS: SENSORS
    • IR-64829
    • METIS-251033
    • EC Grant Agreement nr.: FP6/034562

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