Fibrinogen polymorphisms are not associated with the risk of myocardial infarction

Catharina Jacoba Maria Doggen, R.M. Bertina, V. Manger Cats, F.R. Rosendaal

Research output: Contribution to journalArticleAcademic

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Abstract

In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms in the α- and β-fibrinogen genes among 560 patients with a myocardial infarction and 646 control subjects. Secondly, we studied the relationships between these polymorphisms and fibrinogen activity and antigen levels. The TaqI, HaeIII and BclI polymorphisms in the fibrinogen gene were not associated with myocardial infarction. As we found an association of the rare B2 allele with fibrinogen levels and a similar, but weak, effect for the rare H2 allele, we conclude that a genetic propensity to high fibrinogen levels does not affect the risk of myocardial infarction. This is evidence against a causal role for fibrinogen levels in the aetiology of myocardial infarction
Original languageUndefined
Pages (from-to)935-938
JournalBritish journal of haematology - Supplement
Volume110
Issue number4
DOIs
Publication statusPublished - 2000

Keywords

  • IR-77840

Cite this

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abstract = "In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms in the α- and β-fibrinogen genes among 560 patients with a myocardial infarction and 646 control subjects. Secondly, we studied the relationships between these polymorphisms and fibrinogen activity and antigen levels. The TaqI, HaeIII and BclI polymorphisms in the fibrinogen gene were not associated with myocardial infarction. As we found an association of the rare B2 allele with fibrinogen levels and a similar, but weak, effect for the rare H2 allele, we conclude that a genetic propensity to high fibrinogen levels does not affect the risk of myocardial infarction. This is evidence against a causal role for fibrinogen levels in the aetiology of myocardial infarction",
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Fibrinogen polymorphisms are not associated with the risk of myocardial infarction. / Doggen, Catharina Jacoba Maria; Bertina, R.M.; Manger Cats, V.; Rosendaal, F.R.

In: British journal of haematology - Supplement, Vol. 110, No. 4, 2000, p. 935-938.

Research output: Contribution to journalArticleAcademic

TY - JOUR

T1 - Fibrinogen polymorphisms are not associated with the risk of myocardial infarction

AU - Doggen, Catharina Jacoba Maria

AU - Bertina, R.M.

AU - Manger Cats, V.

AU - Rosendaal, F.R.

PY - 2000

Y1 - 2000

N2 - In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms in the α- and β-fibrinogen genes among 560 patients with a myocardial infarction and 646 control subjects. Secondly, we studied the relationships between these polymorphisms and fibrinogen activity and antigen levels. The TaqI, HaeIII and BclI polymorphisms in the fibrinogen gene were not associated with myocardial infarction. As we found an association of the rare B2 allele with fibrinogen levels and a similar, but weak, effect for the rare H2 allele, we conclude that a genetic propensity to high fibrinogen levels does not affect the risk of myocardial infarction. This is evidence against a causal role for fibrinogen levels in the aetiology of myocardial infarction

AB - In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms in the α- and β-fibrinogen genes among 560 patients with a myocardial infarction and 646 control subjects. Secondly, we studied the relationships between these polymorphisms and fibrinogen activity and antigen levels. The TaqI, HaeIII and BclI polymorphisms in the fibrinogen gene were not associated with myocardial infarction. As we found an association of the rare B2 allele with fibrinogen levels and a similar, but weak, effect for the rare H2 allele, we conclude that a genetic propensity to high fibrinogen levels does not affect the risk of myocardial infarction. This is evidence against a causal role for fibrinogen levels in the aetiology of myocardial infarction

KW - IR-77840

U2 - 10.1046/j.1365-2141.2000.02266.x

DO - 10.1046/j.1365-2141.2000.02266.x

M3 - Article

VL - 110

SP - 935

EP - 938

JO - British journal of haematology - Supplement

JF - British journal of haematology - Supplement

SN - 0963-1860

IS - 4

ER -