Field-effect pH Control in Nanochannels

R.B.H. Veenhuis, E.J. van der Wouden, Jan William van Nieuwkasteele, Albert van den Berg, Jan C.T. Eijkel

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    We demonstrate a novel capacitive method to change the pH in nanochannels. The device employs metal electrodes outside an insulating channel wall to change the electrical double layer potential by the field effect (‘voltage gating’). We demonstrate that this potential change is accompanied by a release or uptake of protons from surface groups, resulting in a pH shift in the nanochannel, and a titration of solution compounds present. This pH actuation method avoids redox reactions and can be very useful as a “soft��? way to change the pH in small volumes e.g. in bioassays or cell-based research, but also for detection in separation methods. We demonstrate the detection of 100 attomol of TRIS in the detection volume by titration. Importantly, the proton release mechanism does not rely on double layer overlap.
    Original languageUndefined
    Title of host publicationThirteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTas 2009)
    EditorsTae Song Kim, Yoon-Sik Lee, Taek-Dong Chung, Noo Li Jeon, Sang-Hoon Lee, Kaph-Yang Suh, Jaebum Choo, Yong-Kweon Kim
    Place of PublicationSan Diego
    PublisherChemical and Biological Society
    Pages1512-1514
    Number of pages3
    ISBN (Print)978-0-9798064-2-1
    Publication statusPublished - 1 Nov 2009
    Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009 - Jeju, Korea, Republic of
    Duration: 1 Nov 20095 Nov 2009
    Conference number: 13

    Publication series

    Name
    PublisherChemical and Biological Society
    Volume2

    Conference

    Conference13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009
    Abbreviated titleMicroTAS
    CountryKorea, Republic of
    CityJeju
    Period1/11/095/11/09

    Keywords

    • IR-68961
    • METIS-264255
    • pH control
    • EWI-17029
    • Nanochannel
    • Nanofluidics
    • titration
    • actuation

    Cite this

    Veenhuis, R. B. H., van der Wouden, E. J., van Nieuwkasteele, J. W., van den Berg, A., & Eijkel, J. C. T. (2009). Field-effect pH Control in Nanochannels. In T. S. Kim, Y-S. Lee, T-D. Chung, N. L. Jeon, S-H. Lee, K-Y. Suh, J. Choo, ... Y-K. Kim (Eds.), Thirteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTas 2009) (pp. 1512-1514). San Diego: Chemical and Biological Society.