Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering

Lorenzo Moroni, F.M. Lambers, W. Wilson, C.C. van Donkelaar, J.R. de Wijn, R. Huiskes, Clemens van Blitterswijk

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Abstract

Solid Free-Form Fabrication (SFF) technologies allow the fabrication of anatomical 3D scaffolds from computer tomography (CT) or magnetic resonance imaging (MRI) patients’ dataset. These structures can be designed and fabricated with a variable, interconnected and accessible porous network, resulting in modulable mechanical properties, permeability, and architecture that can be tailored to mimic a specific tissue to replace or regenerate. In this study, we evaluated whether anatomical meniscal 3D scaffolds with matching mechanical properties and architecture are beneficial for meniscus replacement as compared to meniscectomy. After acquiring CT and MRI of porcine menisci, 3D fiber-deposited (3DF) scaffolds were fabricated with different architectures by varying the deposition pattern of the fibers comprising the final structure. The mechanical behaviour of 3DF scaffolds with different architectures and of porcine menisci was measured by static and dynamic mechanical analysis and the effect of these tissue engineering templates on articular cartilage was assessed by finite element analysis (FEA) and compared to healthy conditions or to meniscectomy. Results show that 3DF anatomical menisci scaffolds can be fabricated with pore different architectures and with mechanical properties matching those of natural menisci. FEA predicted a beneficial effect of meniscus replacement with 3D scaffolds in different mechanical loading conditions as compared to meniscectomy. No influence of the internal scaffold architecture was found on articular cartilage damage. Although FEA predictions should be further confirmed by in vitro and in vivo experiments, this study highlights meniscus replacement by SFF anatomical scaffolds as a potential alternative to meniscectomy.
Original languageEnglish
Pages (from-to)23-34
JournalOpen biomedical engineering journal
Volume1
DOIs
Publication statusPublished - 2007

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Finite Element Analysis
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Scaffolds
Finite element method
Layered manufacturing
Articular Cartilage
Fibers
Cartilage
Magnetic resonance
Mechanical properties
Swine
Tomography
Magnetic Resonance Imaging
Imaging techniques
Meniscus
Dynamic mechanical analysis
Permeability
Technology

Keywords

  • METIS-322148
  • IR-104598

Cite this

Moroni, L., Lambers, F. M., Wilson, W., van Donkelaar, C. C., de Wijn, J. R., Huiskes, R., & van Blitterswijk, C. (2007). Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering. Open biomedical engineering journal, 1, 23-34. https://doi.org/10.2174/1874120700701010023
Moroni, Lorenzo ; Lambers, F.M. ; Wilson, W. ; van Donkelaar, C.C. ; de Wijn, J.R. ; Huiskes, R. ; van Blitterswijk, Clemens. / Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering. In: Open biomedical engineering journal. 2007 ; Vol. 1. pp. 23-34.
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abstract = "Solid Free-Form Fabrication (SFF) technologies allow the fabrication of anatomical 3D scaffolds from computer tomography (CT) or magnetic resonance imaging (MRI) patients’ dataset. These structures can be designed and fabricated with a variable, interconnected and accessible porous network, resulting in modulable mechanical properties, permeability, and architecture that can be tailored to mimic a specific tissue to replace or regenerate. In this study, we evaluated whether anatomical meniscal 3D scaffolds with matching mechanical properties and architecture are beneficial for meniscus replacement as compared to meniscectomy. After acquiring CT and MRI of porcine menisci, 3D fiber-deposited (3DF) scaffolds were fabricated with different architectures by varying the deposition pattern of the fibers comprising the final structure. The mechanical behaviour of 3DF scaffolds with different architectures and of porcine menisci was measured by static and dynamic mechanical analysis and the effect of these tissue engineering templates on articular cartilage was assessed by finite element analysis (FEA) and compared to healthy conditions or to meniscectomy. Results show that 3DF anatomical menisci scaffolds can be fabricated with pore different architectures and with mechanical properties matching those of natural menisci. FEA predicted a beneficial effect of meniscus replacement with 3D scaffolds in different mechanical loading conditions as compared to meniscectomy. No influence of the internal scaffold architecture was found on articular cartilage damage. Although FEA predictions should be further confirmed by in vitro and in vivo experiments, this study highlights meniscus replacement by SFF anatomical scaffolds as a potential alternative to meniscectomy.",
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Moroni, L, Lambers, FM, Wilson, W, van Donkelaar, CC, de Wijn, JR, Huiskes, R & van Blitterswijk, C 2007, 'Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering' Open biomedical engineering journal, vol. 1, pp. 23-34. https://doi.org/10.2174/1874120700701010023

Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering. / Moroni, Lorenzo; Lambers, F.M.; Wilson, W.; van Donkelaar, C.C.; de Wijn, J.R.; Huiskes, R.; van Blitterswijk, Clemens.

In: Open biomedical engineering journal, Vol. 1, 2007, p. 23-34.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering

AU - Moroni, Lorenzo

AU - Lambers, F.M.

AU - Wilson, W.

AU - van Donkelaar, C.C.

AU - de Wijn, J.R.

AU - Huiskes, R.

AU - van Blitterswijk, Clemens

N1 - Open access

PY - 2007

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AB - Solid Free-Form Fabrication (SFF) technologies allow the fabrication of anatomical 3D scaffolds from computer tomography (CT) or magnetic resonance imaging (MRI) patients’ dataset. These structures can be designed and fabricated with a variable, interconnected and accessible porous network, resulting in modulable mechanical properties, permeability, and architecture that can be tailored to mimic a specific tissue to replace or regenerate. In this study, we evaluated whether anatomical meniscal 3D scaffolds with matching mechanical properties and architecture are beneficial for meniscus replacement as compared to meniscectomy. After acquiring CT and MRI of porcine menisci, 3D fiber-deposited (3DF) scaffolds were fabricated with different architectures by varying the deposition pattern of the fibers comprising the final structure. The mechanical behaviour of 3DF scaffolds with different architectures and of porcine menisci was measured by static and dynamic mechanical analysis and the effect of these tissue engineering templates on articular cartilage was assessed by finite element analysis (FEA) and compared to healthy conditions or to meniscectomy. Results show that 3DF anatomical menisci scaffolds can be fabricated with pore different architectures and with mechanical properties matching those of natural menisci. FEA predicted a beneficial effect of meniscus replacement with 3D scaffolds in different mechanical loading conditions as compared to meniscectomy. No influence of the internal scaffold architecture was found on articular cartilage damage. Although FEA predictions should be further confirmed by in vitro and in vivo experiments, this study highlights meniscus replacement by SFF anatomical scaffolds as a potential alternative to meniscectomy.

KW - METIS-322148

KW - IR-104598

U2 - 10.2174/1874120700701010023

DO - 10.2174/1874120700701010023

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VL - 1

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JO - Open biomedical engineering journal

JF - Open biomedical engineering journal

SN - 1874-1207

ER -