First clinical trials of the Twente Photoacoustic Mammoscope (PAM)

Susanne E. Vaartjes, Johan C.G. Van Hespen, Joost M. Klaase, Frank M. Van Den Engh, Andy K.H. Thé, Wiendelt Steenbergen, Ton G. Van Leeuwen, Srirang Manohar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

6 Citations (Scopus)


Breast cancer dominates cancers in females. This burden on society and the room for improvements in the current practice of mammography have been stimuli for developing new modalities like photoacoustic mammography. At the University of Twente (UT), an instrument had been developed aimed at performing limited area scans on the human breast. This instrument is called the Twente Photoacoustic Mammoscope (PAM). The PAM is based on generating laser-induced ultrasound from absorbing structures in the breast. The heart of the instrument is a flat PVDF based detector matrix comprising 590 active elements. We show the performance characteristics of the ultrasound detector. The exciting source is an Nd:YAG laser operating at 1064 nm with 5 ns pulses. A study protocol was designed to explore the feasibility of using the PAM to detect cancer in the breasts of patients. The protocol was executed at the Medisch Spectrum Twente by using the mammoscope to obtain photoacoustic region-of-interest (ROI) images of the suspect/symptomatic breasts. We compare the photoacoustic images obtained with x-ray mammograms and ultrasound images. We show photoacoustic images of ROI in one case where we attribute high intensity regions to tumor vascularization.

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2007
PublisherOptical Society of America
ISBN (Print)0819467731, 9780819467737
Publication statusPublished - 26 Nov 2007
EventEuropean Conferences on Biomedical Optics, ECBO 2007 - ICM—International Conference Centre Munich, Munich, Germany
Duration: 17 Jun 200721 Jun 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceEuropean Conferences on Biomedical Optics, ECBO 2007
Abbreviated titleECBO


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