First in vivo results of a novel pediatric oxygenator with an integrated pulsatile pump

Katharina Stang; Ralf Borchardt; Bernd Neumann; Julia Kurz; Sandra Stoppelkamp; Tim O. Greiner; Christine Fahrner; Martin Schenk; Christian Schlensak; Maria Schubert; Henning Lausberg; Sabine Herold; Peter C. Schlanstein; Ulrich Steinseifer; Jutta Arens; Hans Peter Wendel

doi:10.1097/MAT.0000000000000256

First in vivo results of a novel pediatric oxygenator with an integrated pulsatile pump

Katharina Stang, Ralf Borchardt, Bernd Neumann, Julia Kurz, Sandra Stoppelkamp, Tim O. Greiner, Christine Fahrner, Martin Schenk, Christian Schlensak, Maria Schubert, Henning Lausberg, Sabine Herold, Peter C. Schlanstein, Ulrich Steinseifer, Jutta Arens, Hans Peter Wendel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

Extracorporeal membrane oxygenation (ECMO) is a pivotal bridge to recovery for cardiopulmonary failure in children. Besides its life-saving quality, it is often associated with severe system-related complications, such as hemolysis, inflammation, and thromboembolism. Novel oxygenator and pump systems may reduce such ECMO-related complications. The ExMeTrA oxygenator is a newly designed pediatric oxygenator with an integrated pulsatile pump minimizing the priming volume and reducing the surface area of blood contact. The aim of our study was to investigate the feasibility and safety of this new ExMeTrA (expansion mediated transport and accumulation) oxygenator in an animal model. During 6 h of extracorporeal circulation (ECC) in pigs, parameters of the hemostatic system including coagulation, platelets and complement activation, and flow rates were investigated. A nonsignificant trend in C3 consumption, thrombin-antithrombin-III (TAT) complex formation and a slight trend in hemolysis were detected. During the ECC, the blood flow was constantly at 500 ml/min using only flexible silicone tubes inside the oxygenator as pulsatile pump. Our data clearly indicate that the hemostatic markers were only slightly influenced by the ExMeTrA oxygenator. Additionally, the oxygenator showed a constant quality of blood flow. Therefore, this novel pediatric oxygenator shows the potential to be used in pediatric and neonatal support with ECMO.

Original language	English
Pages (from-to)	574-582
Number of pages	9
Journal	ASAIO Journal
Volume	61
Issue number	5
DOIs	https://doi.org/10.1097/MAT.0000000000000256
Publication status	Published - 1 Oct 2015
Externally published	Yes

Keywords

extra corporeal membrane oxygenation
in vivo experiment
oxygenator
pediatric patients
pulsatile flow

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10.1097/MAT.0000000000000256

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Stang, K., Borchardt, R., Neumann, B., Kurz, J., Stoppelkamp, S., Greiner, T. O., Fahrner, C., Schenk, M., Schlensak, C., Schubert, M., Lausberg, H., Herold, S., Schlanstein, P. C., Steinseifer, U., Arens, J., & Wendel, H. P. (2015). First in vivo results of a novel pediatric oxygenator with an integrated pulsatile pump. ASAIO Journal, 61(5), 574-582. https://doi.org/10.1097/MAT.0000000000000256

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title = "First in vivo results of a novel pediatric oxygenator with an integrated pulsatile pump",

abstract = "Extracorporeal membrane oxygenation (ECMO) is a pivotal bridge to recovery for cardiopulmonary failure in children. Besides its life-saving quality, it is often associated with severe system-related complications, such as hemolysis, inflammation, and thromboembolism. Novel oxygenator and pump systems may reduce such ECMO-related complications. The ExMeTrA oxygenator is a newly designed pediatric oxygenator with an integrated pulsatile pump minimizing the priming volume and reducing the surface area of blood contact. The aim of our study was to investigate the feasibility and safety of this new ExMeTrA (expansion mediated transport and accumulation) oxygenator in an animal model. During 6 h of extracorporeal circulation (ECC) in pigs, parameters of the hemostatic system including coagulation, platelets and complement activation, and flow rates were investigated. A nonsignificant trend in C3 consumption, thrombin-antithrombin-III (TAT) complex formation and a slight trend in hemolysis were detected. During the ECC, the blood flow was constantly at 500 ml/min using only flexible silicone tubes inside the oxygenator as pulsatile pump. Our data clearly indicate that the hemostatic markers were only slightly influenced by the ExMeTrA oxygenator. Additionally, the oxygenator showed a constant quality of blood flow. Therefore, this novel pediatric oxygenator shows the potential to be used in pediatric and neonatal support with ECMO.",

keywords = "extra corporeal membrane oxygenation, in vivo experiment, oxygenator, pediatric patients, pulsatile flow",

author = "Katharina Stang and Ralf Borchardt and Bernd Neumann and Julia Kurz and Sandra Stoppelkamp and Greiner, {Tim O.} and Christine Fahrner and Martin Schenk and Christian Schlensak and Maria Schubert and Henning Lausberg and Sabine Herold and Schlanstein, {Peter C.} and Ulrich Steinseifer and Jutta Arens and Wendel, {Hans Peter}",

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Stang, K, Borchardt, R, Neumann, B, Kurz, J, Stoppelkamp, S, Greiner, TO, Fahrner, C, Schenk, M, Schlensak, C, Schubert, M, Lausberg, H, Herold, S, Schlanstein, PC, Steinseifer, U, Arens, J & Wendel, HP 2015, 'First in vivo results of a novel pediatric oxygenator with an integrated pulsatile pump', ASAIO Journal, vol. 61, no. 5, pp. 574-582. https://doi.org/10.1097/MAT.0000000000000256

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T1 - First in vivo results of a novel pediatric oxygenator with an integrated pulsatile pump

AU - Stang, Katharina

AU - Borchardt, Ralf

AU - Neumann, Bernd

AU - Kurz, Julia

AU - Stoppelkamp, Sandra

AU - Greiner, Tim O.

AU - Fahrner, Christine

AU - Schenk, Martin

AU - Schlensak, Christian

AU - Schubert, Maria

AU - Lausberg, Henning

AU - Herold, Sabine

AU - Schlanstein, Peter C.

AU - Steinseifer, Ulrich

AU - Arens, Jutta

AU - Wendel, Hans Peter

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Extracorporeal membrane oxygenation (ECMO) is a pivotal bridge to recovery for cardiopulmonary failure in children. Besides its life-saving quality, it is often associated with severe system-related complications, such as hemolysis, inflammation, and thromboembolism. Novel oxygenator and pump systems may reduce such ECMO-related complications. The ExMeTrA oxygenator is a newly designed pediatric oxygenator with an integrated pulsatile pump minimizing the priming volume and reducing the surface area of blood contact. The aim of our study was to investigate the feasibility and safety of this new ExMeTrA (expansion mediated transport and accumulation) oxygenator in an animal model. During 6 h of extracorporeal circulation (ECC) in pigs, parameters of the hemostatic system including coagulation, platelets and complement activation, and flow rates were investigated. A nonsignificant trend in C3 consumption, thrombin-antithrombin-III (TAT) complex formation and a slight trend in hemolysis were detected. During the ECC, the blood flow was constantly at 500 ml/min using only flexible silicone tubes inside the oxygenator as pulsatile pump. Our data clearly indicate that the hemostatic markers were only slightly influenced by the ExMeTrA oxygenator. Additionally, the oxygenator showed a constant quality of blood flow. Therefore, this novel pediatric oxygenator shows the potential to be used in pediatric and neonatal support with ECMO.

AB - Extracorporeal membrane oxygenation (ECMO) is a pivotal bridge to recovery for cardiopulmonary failure in children. Besides its life-saving quality, it is often associated with severe system-related complications, such as hemolysis, inflammation, and thromboembolism. Novel oxygenator and pump systems may reduce such ECMO-related complications. The ExMeTrA oxygenator is a newly designed pediatric oxygenator with an integrated pulsatile pump minimizing the priming volume and reducing the surface area of blood contact. The aim of our study was to investigate the feasibility and safety of this new ExMeTrA (expansion mediated transport and accumulation) oxygenator in an animal model. During 6 h of extracorporeal circulation (ECC) in pigs, parameters of the hemostatic system including coagulation, platelets and complement activation, and flow rates were investigated. A nonsignificant trend in C3 consumption, thrombin-antithrombin-III (TAT) complex formation and a slight trend in hemolysis were detected. During the ECC, the blood flow was constantly at 500 ml/min using only flexible silicone tubes inside the oxygenator as pulsatile pump. Our data clearly indicate that the hemostatic markers were only slightly influenced by the ExMeTrA oxygenator. Additionally, the oxygenator showed a constant quality of blood flow. Therefore, this novel pediatric oxygenator shows the potential to be used in pediatric and neonatal support with ECMO.

KW - extra corporeal membrane oxygenation

KW - in vivo experiment

KW - oxygenator

KW - pediatric patients

KW - pulsatile flow

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U2 - 10.1097/MAT.0000000000000256

DO - 10.1097/MAT.0000000000000256

M3 - Article

C2 - 26098176

AN - SCOPUS:84954114012

SN - 1058-2916

VL - 61

SP - 574

EP - 582

JO - ASAIO Journal

JF - ASAIO Journal

IS - 5

ER -

First in vivo results of a novel pediatric oxygenator with an integrated pulsatile pump

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Keywords

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