Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Laminar flow patterning is an iconic microfluidic technology used to locally deliver chemicals to specific regions on a two-dimensional surface with high spatial fidelity. Here we present a novel extension of this technology by flow patterning inside cured, three-dimensional (3D) hydrogels. We control the pressures at the inlets to shape the size and position of a region of high solute concentration in the main channel filled with a cured collagen 1 hydrogel. This method allows solutes to be delivered with 50 micron accuracy within the gel, as evidenced by control of concentration profiles of 40 kDa fluorescent dye.
Original languageEnglish
Title of host publicationMicroTAS2018 The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences
EditorsGwo-Bin Lee, Fan-Gang Tseng
PublisherThe Chemical and Biological Microsystems Society
Pages2239-2241
Number of pages3
ISBN (Print)978-0-578-40530-8
Publication statusPublished - 11 Nov 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China
Duration: 10 Nov 201815 Nov 2018
Conference number: 22
https://cbmsociety.org/conferences/microtas2018/

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Abbreviated titleMicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period10/11/1815/11/18
Internet address

Fingerprint

solute
gel
collagen
laminar flow
dye
method
chemical

Cite this

Loessberg-Zahl, J., van der Meer, A. D., van den Berg, A., & Eijkel, J. C. T. (2018). Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices. In G-B. Lee, & F-G. T. (Eds.), MicroTAS2018 The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2239-2241). The Chemical and Biological Microsystems Society.
Loessberg-Zahl, Joshua ; van der Meer, Andries D. ; van den Berg, Albert ; Eijkel, Jan C.T. / Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices. MicroTAS2018 The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. editor / Gwo-Bin Lee ; Fan-Gang Tseng. The Chemical and Biological Microsystems Society, 2018. pp. 2239-2241
@inproceedings{ff5e54a74ffa4d61b384f2108b322348,
title = "Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices",
abstract = "Laminar flow patterning is an iconic microfluidic technology used to locally deliver chemicals to specific regions on a two-dimensional surface with high spatial fidelity. Here we present a novel extension of this technology by flow patterning inside cured, three-dimensional (3D) hydrogels. We control the pressures at the inlets to shape the size and position of a region of high solute concentration in the main channel filled with a cured collagen 1 hydrogel. This method allows solutes to be delivered with 50 micron accuracy within the gel, as evidenced by control of concentration profiles of 40 kDa fluorescent dye.",
author = "Joshua Loessberg-Zahl and {van der Meer}, {Andries D.} and {van den Berg}, Albert and Eijkel, {Jan C.T.}",
year = "2018",
month = "11",
day = "11",
language = "English",
isbn = "978-0-578-40530-8",
pages = "2239--2241",
editor = "Gwo-Bin Lee and {Fan-Gang Tseng}",
booktitle = "MicroTAS2018 The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "The Chemical and Biological Microsystems Society",

}

Loessberg-Zahl, J, van der Meer, AD, van den Berg, A & Eijkel, JCT 2018, Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices. in G-B Lee & F-GT (eds), MicroTAS2018 The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, pp. 2239-2241, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, Kaohsiung, Taiwan, Province of China, 10/11/18.

Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices. / Loessberg-Zahl, Joshua; van der Meer, Andries D.; van den Berg, Albert ; Eijkel, Jan C.T.

MicroTAS2018 The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / Gwo-Bin Lee; Fan-Gang Tseng. The Chemical and Biological Microsystems Society, 2018. p. 2239-2241.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices

AU - Loessberg-Zahl, Joshua

AU - van der Meer, Andries D.

AU - van den Berg, Albert

AU - Eijkel, Jan C.T.

PY - 2018/11/11

Y1 - 2018/11/11

N2 - Laminar flow patterning is an iconic microfluidic technology used to locally deliver chemicals to specific regions on a two-dimensional surface with high spatial fidelity. Here we present a novel extension of this technology by flow patterning inside cured, three-dimensional (3D) hydrogels. We control the pressures at the inlets to shape the size and position of a region of high solute concentration in the main channel filled with a cured collagen 1 hydrogel. This method allows solutes to be delivered with 50 micron accuracy within the gel, as evidenced by control of concentration profiles of 40 kDa fluorescent dye.

AB - Laminar flow patterning is an iconic microfluidic technology used to locally deliver chemicals to specific regions on a two-dimensional surface with high spatial fidelity. Here we present a novel extension of this technology by flow patterning inside cured, three-dimensional (3D) hydrogels. We control the pressures at the inlets to shape the size and position of a region of high solute concentration in the main channel filled with a cured collagen 1 hydrogel. This method allows solutes to be delivered with 50 micron accuracy within the gel, as evidenced by control of concentration profiles of 40 kDa fluorescent dye.

M3 - Conference contribution

SN - 978-0-578-40530-8

SP - 2239

EP - 2241

BT - MicroTAS2018 The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences

A2 - Lee, Gwo-Bin

A2 - null, Fan-Gang Tseng

PB - The Chemical and Biological Microsystems Society

ER -

Loessberg-Zahl J, van der Meer AD, van den Berg A, Eijkel JCT. Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices. In Lee G-B, F-GT, editors, MicroTAS2018 The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society. 2018. p. 2239-2241