Laminar flow patterning is an iconic microfluidic technology used to locally deliver chemicals to specific regions on a two-dimensional surface with high spatial fidelity. Here we present a novel extension of this technology by flow patterning inside cured, three-dimensional (3D) hydrogels. We control the pressures at the inlets to shape the size and position of a region of high solute concentration in the main channel filled with a cured collagen 1 hydrogel. This method allows solutes to be delivered with 50 micron accuracy within the gel, as evidenced by control of concentration profiles of 40 kDa fluorescent dye.
|Title of host publication||MicroTAS 2018|
|Subtitle of host publication||The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Editors||Gwo-Bin Lee, Fan-Gang Tseng|
|Publisher||The Chemical and Biological Microsystems Society|
|Number of pages||3|
|Publication status||E-pub ahead of print/First online - 11 Nov 2018|
|Event||22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China|
Duration: 10 Nov 2018 → 15 Nov 2018
Conference number: 22
|Conference||22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018|
|Abbreviated title||MicroTAS 2018|
|Country||Taiwan, Province of China|
|Period||10/11/18 → 15/11/18|
Loessberg-Zahl, J., van der Meer, A. D., van den Berg, A., & Eijkel, J. C. T. (2018). Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices. In G-B. Lee, & F-G. T. (Eds.), MicroTAS 2018: The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2239-2241). The Chemical and Biological Microsystems Society.