Fluid Resuscitation in Septic Patients Improves Systolic but not Diastolic Middle Cerebral Artery Flow Velocity

Annika A. de Goede, Bert G. Loef, Auke C. Reidinga, Arjen Schaafsma

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

To investigate the effects of fluid resuscitation on cerebral hemodynamics in sepsis, the following set of transcranial Doppler (TCD) parameters was used: maximal change in flow velocity (FV) during stroke onset (acc), maximal FV during first (sys1) or second (sys2) phase of systole and mean diastolic FV (dias@560). We aim to evaluate changes in cerebral hemodynamics that result from (i) sepsis and (ii) adequate fluid resuscitation in critically ill septic patients. In the majority of 16 septic patients sys2 was initially absent but reappeared during the period of fluid resuscitation; whereas sys2 absence was never seen in healthy controls. Second, adequate fluid resuscitation resulted in a significant increase of the systolic FV components (acc, sys1, sys2 and systolic blood pressure); whereas the diastolic components (dias@560 and diastolic blood pressure) remained unchanged. Sys2 absence and reappearance in sepsis suggests that TCD could become a non-invasive alternative for hemodynamic monitoring.

Original languageEnglish
Pages (from-to)2591-2600
Number of pages10
JournalUltrasound in medicine and biology
Volume43
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

Fingerprint

resuscitation
Middle Cerebral Artery
arteries
Resuscitation
hemodynamics
flow velocity
Blood Pressure
blood pressure
Sepsis
Hemodynamics
fluids
diastolic pressure
systolic pressure
systole
Systole
strokes
Critical Illness
Stroke

Keywords

  • Intra-cranial hemodynamics
  • Resuscitation
  • Sepsis
  • Shock
  • TCD
  • Transcranial Doppler

Cite this

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title = "Fluid Resuscitation in Septic Patients Improves Systolic but not Diastolic Middle Cerebral Artery Flow Velocity",
abstract = "To investigate the effects of fluid resuscitation on cerebral hemodynamics in sepsis, the following set of transcranial Doppler (TCD) parameters was used: maximal change in flow velocity (FV) during stroke onset (acc), maximal FV during first (sys1) or second (sys2) phase of systole and mean diastolic FV (dias@560). We aim to evaluate changes in cerebral hemodynamics that result from (i) sepsis and (ii) adequate fluid resuscitation in critically ill septic patients. In the majority of 16 septic patients sys2 was initially absent but reappeared during the period of fluid resuscitation; whereas sys2 absence was never seen in healthy controls. Second, adequate fluid resuscitation resulted in a significant increase of the systolic FV components (acc, sys1, sys2 and systolic blood pressure); whereas the diastolic components (dias@560 and diastolic blood pressure) remained unchanged. Sys2 absence and reappearance in sepsis suggests that TCD could become a non-invasive alternative for hemodynamic monitoring.",
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Fluid Resuscitation in Septic Patients Improves Systolic but not Diastolic Middle Cerebral Artery Flow Velocity. / de Goede, Annika A.; Loef, Bert G.; Reidinga, Auke C.; Schaafsma, Arjen.

In: Ultrasound in medicine and biology, Vol. 43, No. 11, 01.11.2017, p. 2591-2600.

Research output: Contribution to journalArticleAcademicpeer-review

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