Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography

Wejdan M. Arif, Philip H. Elsinga, Carmen Gasca-Salas, Michel Versluis, Raaúl Martínez-Fernández, Rudi A.J.O. Dierckx, Ronald J.H. Borra, Gert Luurtsema*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promising new application. However, the mechanism of BBB opening by FUS remains unclear. This review focuses on the use of FUS to open the BBB for enhancing drug delivery and investigating how Positron Emission Tomography (PET) provides insight into the underlying mechanism.
Original languageEnglish
Pages (from-to)303-316
Number of pages14
JournalJournal of controlled release
Volume324
Early online date16 May 2020
DOIs
Publication statusPublished - 10 Aug 2020

Keywords

  • Blood-brain barrier transporters
  • FUS
  • Microbubbles
  • Radiotracers

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    Arif, W. M., Elsinga, P. H., Gasca-Salas, C., Versluis, M., Martínez-Fernández, R., Dierckx, R. A. J. O., ... Luurtsema, G. (2020). Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography. Journal of controlled release, 324, 303-316. https://doi.org/10.1016/j.jconrel.2020.05.020