Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study

Hayriye Cagnan, H. Cagnan, Hil Gaétan Ellart Meijer, Stephanus A. van Gils, M. Krupa, Tjitske Heida, Michelle Rudolph, Wyse J. Wadman, Hubert C.F. Martens

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Abstract

In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson's disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low-threshold calcium current dynamics and passive membrane properties of the neuron. STN-DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude.
Original languageUndefined
Article number10.1111/j.1460-9568.2009.06922.x
Pages (from-to)1306-1317
Number of pages12
JournalEuropean journal of neuroscience
Volume30
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • EWI-16424
  • Basal ganglia
  • Modulation
  • IR-68313
  • Relay
  • METIS-266483
  • High-frequency stimulation

Cite this

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title = "Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study",
abstract = "In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson's disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low-threshold calcium current dynamics and passive membrane properties of the neuron. STN-DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude.",
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author = "Hayriye Cagnan and H. Cagnan and Meijer, {Hil Ga{\'e}tan Ellart} and {van Gils}, {Stephanus A.} and M. Krupa and Tjitske Heida and Michelle Rudolph and Wadman, {Wyse J.} and Martens, {Hubert C.F.}",
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language = "Undefined",
volume = "30",
pages = "1306--1317",
journal = "European journal of neuroscience",
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Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study. / Cagnan, Hayriye; Cagnan, H.; Meijer, Hil Gaétan Ellart; van Gils, Stephanus A.; Krupa, M.; Heida, Tjitske; Rudolph, Michelle; Wadman, Wyse J.; Martens, Hubert C.F.

In: European journal of neuroscience, Vol. 30, No. 7, 10.1111/j.1460-9568.2009.06922.x, 2009, p. 1306-1317.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study

AU - Cagnan, Hayriye

AU - Cagnan, H.

AU - Meijer, Hil Gaétan Ellart

AU - van Gils, Stephanus A.

AU - Krupa, M.

AU - Heida, Tjitske

AU - Rudolph, Michelle

AU - Wadman, Wyse J.

AU - Martens, Hubert C.F.

PY - 2009

Y1 - 2009

N2 - In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson's disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low-threshold calcium current dynamics and passive membrane properties of the neuron. STN-DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude.

AB - In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson's disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low-threshold calcium current dynamics and passive membrane properties of the neuron. STN-DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude.

KW - EWI-16424

KW - Basal ganglia

KW - Modulation

KW - IR-68313

KW - Relay

KW - METIS-266483

KW - High-frequency stimulation

U2 - 10.1111/j.1460-9568.2009.06922.x

DO - 10.1111/j.1460-9568.2009.06922.x

M3 - Article

VL - 30

SP - 1306

EP - 1317

JO - European journal of neuroscience

JF - European journal of neuroscience

SN - 0953-816X

IS - 7

M1 - 10.1111/j.1460-9568.2009.06922.x

ER -