From chip-in-a-lab to lab-on-a-chip: a portable Coulter counter using a modular platform

Stefan Dekker, Pelin Kubra Isgor, Tobias Feijten, Loes Segerink, Mathieu Odijk (Corresponding Author)

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    Abstract

    The field of microfluidics has been struggling to obtain widespread market penetration. In order to overcome this struggle, a standardized and modular platform is introduced and applied. By providing easy-to-fabricate modular building blocks which are compatible with mass manufacturing, we decrease the gap from lab-to-fab. These standardized blocks are used in combination with an application-specific fluidic circuit board. On this board, electrical and fluidic connections are demonstrated by implementing an alternating current Coulter counter. This multipurpose building block is reusable in many applications. In this study, it identifies and counts 6 and 11 μm beads. The system is kept in a credit card-sized footprint, as a result of in-house-developed electronics and standardized building blocks. We believe that this easy-to-fabricate, credit card-sized, modular, and standardized prototype brings us closer to clinical and veterinary applications, because it provides an essential stepping stone to fully integrated point -of -care devices.
    Original languageEnglish
    Article number34
    Number of pages8
    JournalMicrosystems & nanoengineering
    Volume4
    DOIs
    Publication statusPublished - 19 Nov 2018

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