From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine

Iwona Cicha; Cédric Chauvierre; Isabelle Texier; Claudia Cabella; Josbert M. Metselaar; János Szebeni; László Dézsi; Christoph Alexiou; François Rouzet; Gert Storm; Erik Stroes; Donald Bruce; Neil MacRitchie; Pasquale Maffia; Didier Letourneur

doi:10.1093/cvr/cvy219

From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine

Iwona Cicha^* (Corresponding Author), Cédric Chauvierre, Isabelle Texier, Claudia Cabella, Josbert M. Metselaar, János Szebeni, László Dézsi, Christoph Alexiou, François Rouzet, Gert Storm, Erik Stroes, Donald Bruce, Neil MacRitchie, Pasquale Maffia, Didier Letourneur

^*Corresponding author for this work

Biomaterials Science and Technology

Research output: Contribution to journal › Review article › Academic › peer-review

20 Citations (Scopus)

Abstract

Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicom-ponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.

Original language	English
Pages (from-to)	1714-1727
Number of pages	14
Journal	Cardiovascular Research
Volume	114
Issue number	13
Early online date	27 Aug 2018
DOIs	https://doi.org/10.1093/cvr/cvy219
Publication status	Published - 1 Nov 2018

Keywords

Cardiovascular nanomedicine
Clinical translation
Nanoparticle design
Nanosafety
Regulatory issues

Access to Document

10.1093/cvr/cvy219

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Cicha, I., Chauvierre, C., Texier, I., Cabella, C., Metselaar, J. M., Szebeni, J., Dézsi, L., Alexiou, C., Rouzet, F., Storm, G., Stroes, E., Bruce, D., MacRitchie, N., Maffia, P., & Letourneur, D. (2018). From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine. Cardiovascular Research, 114(13), 1714-1727. https://doi.org/10.1093/cvr/cvy219

Cicha, Iwona ; Chauvierre, Cédric ; Texier, Isabelle ; Cabella, Claudia ; Metselaar, Josbert M. ; Szebeni, János ; Dézsi, László ; Alexiou, Christoph ; Rouzet, François ; Storm, Gert ; Stroes, Erik ; Bruce, Donald ; MacRitchie, Neil ; Maffia, Pasquale ; Letourneur, Didier. / From design to the clinic : Practical guidelines for translating cardiovascular nanomedicine. In: Cardiovascular Research. 2018 ; Vol. 114, No. 13. pp. 1714-1727.

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abstract = "Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicom-ponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.",

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Cicha, I, Chauvierre, C, Texier, I, Cabella, C, Metselaar, JM, Szebeni, J, Dézsi, L, Alexiou, C, Rouzet, F, Storm, G, Stroes, E, Bruce, D, MacRitchie, N, Maffia, P & Letourneur, D 2018, 'From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine', Cardiovascular Research, vol. 114, no. 13, pp. 1714-1727. https://doi.org/10.1093/cvr/cvy219

From design to the clinic : Practical guidelines for translating cardiovascular nanomedicine. / Cicha, Iwona (Corresponding Author); Chauvierre, Cédric; Texier, Isabelle; Cabella, Claudia; Metselaar, Josbert M.; Szebeni, János; Dézsi, László; Alexiou, Christoph; Rouzet, François; Storm, Gert; Stroes, Erik; Bruce, Donald; MacRitchie, Neil; Maffia, Pasquale; Letourneur, Didier.

In: Cardiovascular Research, Vol. 114, No. 13, 01.11.2018, p. 1714-1727.

Research output: Contribution to journal › Review article › Academic › peer-review

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