From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine

Iwona Cicha (Corresponding Author), Cédric Chauvierre, Isabelle Texier, Claudia Cabella, Josbert M. Metselaar, János Szebeni, László Dézsi, Christoph Alexiou, François Rouzet, Gert Storm, Erik Stroes, Donald Bruce, Neil MacRitchie, Pasquale Maffia, Didier Letourneur

Research output: Contribution to journalReview articleAcademicpeer-review

4 Citations (Scopus)

Abstract

Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicom-ponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.

Original languageEnglish
Pages (from-to)1714-1727
Number of pages14
JournalCardiovascular Research
Volume114
Issue number13
Early online date27 Aug 2018
DOIs
Publication statusPublished - 1 Nov 2018

Fingerprint

Nanomedicine
Cardiovascular Diseases
Guidelines
Nanoparticles
Obesity
Safety
Equipment and Supplies
Mortality

Keywords

  • Cardiovascular nanomedicine
  • Clinical translation
  • Nanoparticle design
  • Nanosafety
  • Regulatory issues

Cite this

Cicha, I., Chauvierre, C., Texier, I., Cabella, C., Metselaar, J. M., Szebeni, J., ... Letourneur, D. (2018). From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine. Cardiovascular Research, 114(13), 1714-1727. https://doi.org/10.1093/cvr/cvy219
Cicha, Iwona ; Chauvierre, Cédric ; Texier, Isabelle ; Cabella, Claudia ; Metselaar, Josbert M. ; Szebeni, János ; Dézsi, László ; Alexiou, Christoph ; Rouzet, François ; Storm, Gert ; Stroes, Erik ; Bruce, Donald ; MacRitchie, Neil ; Maffia, Pasquale ; Letourneur, Didier. / From design to the clinic : Practical guidelines for translating cardiovascular nanomedicine. In: Cardiovascular Research. 2018 ; Vol. 114, No. 13. pp. 1714-1727.
@article{4dca4a7401eb488b9efbe3182f084b38,
title = "From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine",
abstract = "Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30{\%} of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicom-ponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.",
keywords = "Cardiovascular nanomedicine, Clinical translation, Nanoparticle design, Nanosafety, Regulatory issues",
author = "Iwona Cicha and C{\'e}dric Chauvierre and Isabelle Texier and Claudia Cabella and Metselaar, {Josbert M.} and J{\'a}nos Szebeni and L{\'a}szl{\'o} D{\'e}zsi and Christoph Alexiou and Fran{\cc}ois Rouzet and Gert Storm and Erik Stroes and Donald Bruce and Neil MacRitchie and Pasquale Maffia and Didier Letourneur",
year = "2018",
month = "11",
day = "1",
doi = "10.1093/cvr/cvy219",
language = "English",
volume = "114",
pages = "1714--1727",
journal = "Cardiovascular Research",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "13",

}

Cicha, I, Chauvierre, C, Texier, I, Cabella, C, Metselaar, JM, Szebeni, J, Dézsi, L, Alexiou, C, Rouzet, F, Storm, G, Stroes, E, Bruce, D, MacRitchie, N, Maffia, P & Letourneur, D 2018, 'From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine' Cardiovascular Research, vol. 114, no. 13, pp. 1714-1727. https://doi.org/10.1093/cvr/cvy219

From design to the clinic : Practical guidelines for translating cardiovascular nanomedicine. / Cicha, Iwona (Corresponding Author); Chauvierre, Cédric; Texier, Isabelle; Cabella, Claudia; Metselaar, Josbert M.; Szebeni, János; Dézsi, László; Alexiou, Christoph; Rouzet, François; Storm, Gert; Stroes, Erik; Bruce, Donald; MacRitchie, Neil; Maffia, Pasquale; Letourneur, Didier.

In: Cardiovascular Research, Vol. 114, No. 13, 01.11.2018, p. 1714-1727.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - From design to the clinic

T2 - Practical guidelines for translating cardiovascular nanomedicine

AU - Cicha, Iwona

AU - Chauvierre, Cédric

AU - Texier, Isabelle

AU - Cabella, Claudia

AU - Metselaar, Josbert M.

AU - Szebeni, János

AU - Dézsi, László

AU - Alexiou, Christoph

AU - Rouzet, François

AU - Storm, Gert

AU - Stroes, Erik

AU - Bruce, Donald

AU - MacRitchie, Neil

AU - Maffia, Pasquale

AU - Letourneur, Didier

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicom-ponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.

AB - Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicom-ponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.

KW - Cardiovascular nanomedicine

KW - Clinical translation

KW - Nanoparticle design

KW - Nanosafety

KW - Regulatory issues

UR - http://www.scopus.com/inward/record.url?scp=85055207494&partnerID=8YFLogxK

U2 - 10.1093/cvr/cvy219

DO - 10.1093/cvr/cvy219

M3 - Review article

VL - 114

SP - 1714

EP - 1727

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 13

ER -

Cicha I, Chauvierre C, Texier I, Cabella C, Metselaar JM, Szebeni J et al. From design to the clinic: Practical guidelines for translating cardiovascular nanomedicine. Cardiovascular Research. 2018 Nov 1;114(13):1714-1727. https://doi.org/10.1093/cvr/cvy219