There are many efforts today trying to mimic the properties of single cells in order to design chips that are as efficient as cells. However, cells are nature"s nanotechnology engineering at the scale of atoms and molecules. Therefore, it might be better to vision a microchip that utilizes a single cell as experimentation platform. A novel, so-called Lab-in-a-Cell (LIC) concept is described, where advantage is taken of micro/nanotechnological tools to enable precise control of the biochemical cellular environment and possibility to analyze the composition of single cells. This is followed by a review on the present chip solutions for single cell handling and analysis.
|Title of host publication||Microfluidics, BioMEMS, and Medical Microsystems III Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Place of Publication||Bellingham, WA, USA|
|Number of pages||12|
|Publication status||Published - 2005|
|Name||BioMEMS for Living Cells|
Andersson, H., & van den Berg, A. (2005). From lab-on-a-chip to lab-in-a-cell. In Microfluidics, BioMEMS, and Medical Microsystems III Progress in Biomedical Optics and Imaging - Proceedings of SPIE (pp. 1-12). (BioMEMS for Living Cells; Vol. 5718, No. 1). Bellingham, WA, USA: SPIE. https://doi.org/10.1117/12.601553