From portable dialysis to a bioengineered kidney

Maaike K. van Gelder (Corresponding Author), Silvia M. Mihaila (Corresponding Author), Jitske Jansen, Maarten Wester, Marianne C. Verhaar, Jaap A. Joles, Dimitrios Stamatialis, Roos Masereeuw, Karin G.F. Gerritsen

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)
2 Downloads (Pure)

Abstract

Introduction: Since the advent of peritoneal dialysis (PD) in the 1970s, the principles of dialysis have changed little. In the coming decades, several major breakthroughs are expected. Areas covered: Novel wearable and portable dialysis devices for both hemodialysis (HD) and PD are expected first. The HD devices could facilitate more frequent and longer dialysis outside of the hospital, while improving patient’s mobility and autonomy. The PD devices could enhance blood purification and increase technique survival of PD. Further away from clinical application is the bioartificial kidney, containing renal cells. Initially, the bioartificial kidney could be applied for extracorporeal treatment, to partly replace renal tubular endocrine, metabolic, immunoregulatory and secretory functions. Subsequently, intracorporeal treatment may become possible. Expert commentary: Key factors for successful implementation of miniature dialysis devices are patient attitudes and cost-effectiveness. A well-functioning and safe extracorporeal blood circuit is required for HD. For PD, a double lumen PD catheter would optimize performance. Future research should focus on further miniaturization of the urea removal strategy. For the bio-artificial kidney (BAK), cost effectiveness should be determined and a general set of functional requirements should be defined for future studies. For intracorporeal application, water reabsorption will become a major challenge.

Original languageEnglish
Pages (from-to)323-336
Number of pages14
JournalExpert review of medical devices
Volume15
Issue number5
DOIs
Publication statusPublished - 4 May 2018

Fingerprint

Dialysis
Peritoneal Dialysis
Kidney
Renal Dialysis
Equipment and Supplies
Cost-Benefit Analysis
Artificial Kidneys
Miniaturization
Cost effectiveness
Blood
Urea
Catheters
Survival
Water
Purification
Therapeutics

Keywords

  • Bioartificial kidney
  • implantable artificial kidney
  • protein bound uremic toxins
  • renal replacement therapy
  • wearable artificial kidney

Cite this

van Gelder, M. K., Mihaila, S. M., Jansen, J., Wester, M., Verhaar, M. C., Joles, J. A., ... Gerritsen, K. G. F. (2018). From portable dialysis to a bioengineered kidney. Expert review of medical devices, 15(5), 323-336. https://doi.org/10.1080/17434440.2018.1462697
van Gelder, Maaike K. ; Mihaila, Silvia M. ; Jansen, Jitske ; Wester, Maarten ; Verhaar, Marianne C. ; Joles, Jaap A. ; Stamatialis, Dimitrios ; Masereeuw, Roos ; Gerritsen, Karin G.F. / From portable dialysis to a bioengineered kidney. In: Expert review of medical devices. 2018 ; Vol. 15, No. 5. pp. 323-336.
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van Gelder, MK, Mihaila, SM, Jansen, J, Wester, M, Verhaar, MC, Joles, JA, Stamatialis, D, Masereeuw, R & Gerritsen, KGF 2018, 'From portable dialysis to a bioengineered kidney' Expert review of medical devices, vol. 15, no. 5, pp. 323-336. https://doi.org/10.1080/17434440.2018.1462697

From portable dialysis to a bioengineered kidney. / van Gelder, Maaike K. (Corresponding Author); Mihaila, Silvia M. (Corresponding Author); Jansen, Jitske; Wester, Maarten; Verhaar, Marianne C.; Joles, Jaap A.; Stamatialis, Dimitrios; Masereeuw, Roos; Gerritsen, Karin G.F.

In: Expert review of medical devices, Vol. 15, No. 5, 04.05.2018, p. 323-336.

Research output: Contribution to journalReview articleAcademicpeer-review

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T1 - From portable dialysis to a bioengineered kidney

AU - van Gelder, Maaike K.

AU - Mihaila, Silvia M.

AU - Jansen, Jitske

AU - Wester, Maarten

AU - Verhaar, Marianne C.

AU - Joles, Jaap A.

AU - Stamatialis, Dimitrios

AU - Masereeuw, Roos

AU - Gerritsen, Karin G.F.

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KW - implantable artificial kidney

KW - protein bound uremic toxins

KW - renal replacement therapy

KW - wearable artificial kidney

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DO - 10.1080/17434440.2018.1462697

M3 - Review article

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JO - Expert review of medical devices

JF - Expert review of medical devices

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van Gelder MK, Mihaila SM, Jansen J, Wester M, Verhaar MC, Joles JA et al. From portable dialysis to a bioengineered kidney. Expert review of medical devices. 2018 May 4;15(5):323-336. https://doi.org/10.1080/17434440.2018.1462697