Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model

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Abstract

Introduction. Treatment choice for extracranial carotid artery widening, also called aneurysm, is difficult. Blood flow simulation and experimental visualization can be supportive in clinical decision making and patient-specific treatment prediction. This study aims to simulate and validate the effect of flow-diverting stent placement on blood flow characteristics using numerical and in vitro simulation techniques in simplified carotid artery and aneurysm models. Methods. We have developed a workflow from geometry design to flow simulations and in vitro measurements in a carotid aneurysm model. To show feasibility of the numerical simulation part of the workflow that uses an immersed boundary method, we study a model geometry of an extracranial carotid artery aneurysm and put a flow-diverting stent in the aneurysm. We use ultrasound particle image velocimetry (PIV) to visualize experimentally the flow inside the aneurysm model. Results. Feasibility of ultrasound visualization of the flow, virtual flow-diverting stent placement and numerical flow simulation are presented. Flow is resolved to scales much smaller than the cross section of individual wires of the flow-diverting stent. Numerical analysis in stented model introduced 25% reduction of the blood flow inside the aneurysm sac. Quantitative comparison of experimental and numerical results showed agreement in 1D velocity profiles. Discussion/conclusion. We find good numerical convergence of the simulations at appropriate spatial resolutions using the immersed boundary method. This allows us to quantify the changes in the flow in model geometries after deploying a flow-diverting stent. We visualized the physiological blood flow in a 1-to-1 aneurysm model, using PIV, showing a good correspondence to the numerical simulations. The novel workflow enables numerical as well as experimental flow simulations in patient-specific cases before and after flow-diverting stent placement. This may contribute to endovascular treatment prediction.

Original languageEnglish
Title of host publicationMedical Imaging 2019
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
EditorsBaowei Fei, Cristian A. Linte
PublisherSPIE
Volume10951
ISBN (Electronic)9781510625495
DOIs
Publication statusPublished - 8 Mar 2019
EventSPIE Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling - Town and Country Resort & Convention Center, San Diego, United States
Duration: 16 Feb 201921 Feb 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10951
ISSN (Print)1605-7422

Conference

ConferenceSPIE Medical Imaging 2019
CountryUnited States
CitySan Diego
Period16/02/1921/02/19

Fingerprint

Stents
Aneurysm
Ultrasonics
Flow simulation
Blood
Workflow
simulation
Carotid Arteries
blood flow
Rheology
Velocity measurement
Geometry
arteries
Visualization
Patient Simulation
particle image velocimetry
Computer simulation
Numerical analysis
geometry
Decision making

Keywords

  • 3d printed geometry
  • Aneurysm
  • Carotid artery
  • Flow-diverting stent
  • Numerical simulations
  • Ultrasound PIV

Cite this

Mikhal, J., Hoving, A. M., Ong, G. M., & Slump, C. H. (2019). Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model. In B. Fei, & C. A. Linte (Eds.), Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling (Vol. 10951). [1095115] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10951). SPIE. https://doi.org/10.1117/12.2513002
Mikhal, J. ; Hoving, A.M. ; Ong, G.M. ; Slump, C.H. / Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model. Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling. editor / Baowei Fei ; Cristian A. Linte. Vol. 10951 SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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title = "Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model",
abstract = "Introduction. Treatment choice for extracranial carotid artery widening, also called aneurysm, is difficult. Blood flow simulation and experimental visualization can be supportive in clinical decision making and patient-specific treatment prediction. This study aims to simulate and validate the effect of flow-diverting stent placement on blood flow characteristics using numerical and in vitro simulation techniques in simplified carotid artery and aneurysm models. Methods. We have developed a workflow from geometry design to flow simulations and in vitro measurements in a carotid aneurysm model. To show feasibility of the numerical simulation part of the workflow that uses an immersed boundary method, we study a model geometry of an extracranial carotid artery aneurysm and put a flow-diverting stent in the aneurysm. We use ultrasound particle image velocimetry (PIV) to visualize experimentally the flow inside the aneurysm model. Results. Feasibility of ultrasound visualization of the flow, virtual flow-diverting stent placement and numerical flow simulation are presented. Flow is resolved to scales much smaller than the cross section of individual wires of the flow-diverting stent. Numerical analysis in stented model introduced 25{\%} reduction of the blood flow inside the aneurysm sac. Quantitative comparison of experimental and numerical results showed agreement in 1D velocity profiles. Discussion/conclusion. We find good numerical convergence of the simulations at appropriate spatial resolutions using the immersed boundary method. This allows us to quantify the changes in the flow in model geometries after deploying a flow-diverting stent. We visualized the physiological blood flow in a 1-to-1 aneurysm model, using PIV, showing a good correspondence to the numerical simulations. The novel workflow enables numerical as well as experimental flow simulations in patient-specific cases before and after flow-diverting stent placement. This may contribute to endovascular treatment prediction.",
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Mikhal, J, Hoving, AM, Ong, GM & Slump, CH 2019, Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model. in B Fei & CA Linte (eds), Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling. vol. 10951, 1095115, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10951, SPIE, SPIE Medical Imaging 2019, San Diego, United States, 16/02/19. https://doi.org/10.1117/12.2513002

Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model. / Mikhal, J.; Hoving, A.M.; Ong, G.M.; Slump, C.H.

Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling. ed. / Baowei Fei; Cristian A. Linte. Vol. 10951 SPIE, 2019. 1095115 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10951).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model

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N2 - Introduction. Treatment choice for extracranial carotid artery widening, also called aneurysm, is difficult. Blood flow simulation and experimental visualization can be supportive in clinical decision making and patient-specific treatment prediction. This study aims to simulate and validate the effect of flow-diverting stent placement on blood flow characteristics using numerical and in vitro simulation techniques in simplified carotid artery and aneurysm models. Methods. We have developed a workflow from geometry design to flow simulations and in vitro measurements in a carotid aneurysm model. To show feasibility of the numerical simulation part of the workflow that uses an immersed boundary method, we study a model geometry of an extracranial carotid artery aneurysm and put a flow-diverting stent in the aneurysm. We use ultrasound particle image velocimetry (PIV) to visualize experimentally the flow inside the aneurysm model. Results. Feasibility of ultrasound visualization of the flow, virtual flow-diverting stent placement and numerical flow simulation are presented. Flow is resolved to scales much smaller than the cross section of individual wires of the flow-diverting stent. Numerical analysis in stented model introduced 25% reduction of the blood flow inside the aneurysm sac. Quantitative comparison of experimental and numerical results showed agreement in 1D velocity profiles. Discussion/conclusion. We find good numerical convergence of the simulations at appropriate spatial resolutions using the immersed boundary method. This allows us to quantify the changes in the flow in model geometries after deploying a flow-diverting stent. We visualized the physiological blood flow in a 1-to-1 aneurysm model, using PIV, showing a good correspondence to the numerical simulations. The novel workflow enables numerical as well as experimental flow simulations in patient-specific cases before and after flow-diverting stent placement. This may contribute to endovascular treatment prediction.

AB - Introduction. Treatment choice for extracranial carotid artery widening, also called aneurysm, is difficult. Blood flow simulation and experimental visualization can be supportive in clinical decision making and patient-specific treatment prediction. This study aims to simulate and validate the effect of flow-diverting stent placement on blood flow characteristics using numerical and in vitro simulation techniques in simplified carotid artery and aneurysm models. Methods. We have developed a workflow from geometry design to flow simulations and in vitro measurements in a carotid aneurysm model. To show feasibility of the numerical simulation part of the workflow that uses an immersed boundary method, we study a model geometry of an extracranial carotid artery aneurysm and put a flow-diverting stent in the aneurysm. We use ultrasound particle image velocimetry (PIV) to visualize experimentally the flow inside the aneurysm model. Results. Feasibility of ultrasound visualization of the flow, virtual flow-diverting stent placement and numerical flow simulation are presented. Flow is resolved to scales much smaller than the cross section of individual wires of the flow-diverting stent. Numerical analysis in stented model introduced 25% reduction of the blood flow inside the aneurysm sac. Quantitative comparison of experimental and numerical results showed agreement in 1D velocity profiles. Discussion/conclusion. We find good numerical convergence of the simulations at appropriate spatial resolutions using the immersed boundary method. This allows us to quantify the changes in the flow in model geometries after deploying a flow-diverting stent. We visualized the physiological blood flow in a 1-to-1 aneurysm model, using PIV, showing a good correspondence to the numerical simulations. The novel workflow enables numerical as well as experimental flow simulations in patient-specific cases before and after flow-diverting stent placement. This may contribute to endovascular treatment prediction.

KW - 3d printed geometry

KW - Aneurysm

KW - Carotid artery

KW - Flow-diverting stent

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KW - Ultrasound PIV

U2 - 10.1117/12.2513002

DO - 10.1117/12.2513002

M3 - Conference contribution

VL - 10951

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Imaging 2019

A2 - Fei, Baowei

A2 - Linte, Cristian A.

PB - SPIE

ER -

Mikhal J, Hoving AM, Ong GM, Slump CH. Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model. In Fei B, Linte CA, editors, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling. Vol. 10951. SPIE. 2019. 1095115. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2513002