Fumaric acid monoethyel ester-functionalized poly(D-Llactide/N-vinyl-2-pyrrolidone resins for the preparation of tissue engineering scaffolds by stereolithography

J. Jansen, F.P.W. Melchels, Dirk W. Grijpma, Jan Feijen

Research output: Contribution to journalArticleAcademicpeer-review

75 Citations (Scopus)
1 Downloads (Pure)

Abstract

Polymer networks were prepared by photocross-linking fumaric acid monoethyl ester (FAME) functionalized, three-armed poly(d,l-lactide) oligomers using N-vinyl-2-pyrrolidone (NVP) as diluent and comonomer. The use of NVP together with FAME-functionalized oligomers resulted in copolymerization at high rates, and networks with gel contents in excess of 90% were obtained. The hydrophilicity of the poly(d,l-lactide) networks increases with increasing amounts of NVP, networks containing 50 wt % of NVP absorbed 40% of water. As the amount of NVP was increased from 30 to 50 wt %, the Young’s modulus after equilibration in water decreased from 0.8 to 0.2 GPa, as opposed to an increase from 1.5 to 2.1 GPa in the dry state. Mouse preosteoblasts readily adhered and spread onto all prepared networks. Using stereolithography, porous structures with a well-defined gyroid architecture were prepared from these novel materials. This allows the preparation of tissue engineering scaffolds with optimized pore architecture and tunable material properties.
Original languageEnglish
Pages (from-to)214-210
JournalBiomacromolecules
Volume10
Issue number2
DOIs
Publication statusPublished - 18 Dec 2009

Fingerprint

Tissue Scaffolds
Stereolithography
Fumarates
Scaffolds (biology)
Tissue engineering
Oligomers
Esters
Resins
Acids
Hydrophilicity
Copolymerization
Water
Materials properties
Gels
Elastic moduli
Polymers
2-pyrrolidone

Keywords

  • METIS-263283
  • IR-76380
  • EC Grant Agreement nr.: FP6/500465

Cite this

@article{b8e6224f1b844da98818bc17f4526572,
title = "Fumaric acid monoethyel ester-functionalized poly(D-Llactide/N-vinyl-2-pyrrolidone resins for the preparation of tissue engineering scaffolds by stereolithography",
abstract = "Polymer networks were prepared by photocross-linking fumaric acid monoethyl ester (FAME) functionalized, three-armed poly(d,l-lactide) oligomers using N-vinyl-2-pyrrolidone (NVP) as diluent and comonomer. The use of NVP together with FAME-functionalized oligomers resulted in copolymerization at high rates, and networks with gel contents in excess of 90{\%} were obtained. The hydrophilicity of the poly(d,l-lactide) networks increases with increasing amounts of NVP, networks containing 50 wt {\%} of NVP absorbed 40{\%} of water. As the amount of NVP was increased from 30 to 50 wt {\%}, the Young’s modulus after equilibration in water decreased from 0.8 to 0.2 GPa, as opposed to an increase from 1.5 to 2.1 GPa in the dry state. Mouse preosteoblasts readily adhered and spread onto all prepared networks. Using stereolithography, porous structures with a well-defined gyroid architecture were prepared from these novel materials. This allows the preparation of tissue engineering scaffolds with optimized pore architecture and tunable material properties.",
keywords = "METIS-263283, IR-76380, EC Grant Agreement nr.: FP6/500465",
author = "J. Jansen and F.P.W. Melchels and Grijpma, {Dirk W.} and Jan Feijen",
year = "2009",
month = "12",
day = "18",
doi = "10.1021/bm801001r",
language = "English",
volume = "10",
pages = "214--210",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",
number = "2",

}

Fumaric acid monoethyel ester-functionalized poly(D-Llactide/N-vinyl-2-pyrrolidone resins for the preparation of tissue engineering scaffolds by stereolithography. / Jansen, J.; Melchels, F.P.W.; Grijpma, Dirk W.; Feijen, Jan.

In: Biomacromolecules, Vol. 10, No. 2, 18.12.2009, p. 214-210.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Fumaric acid monoethyel ester-functionalized poly(D-Llactide/N-vinyl-2-pyrrolidone resins for the preparation of tissue engineering scaffolds by stereolithography

AU - Jansen, J.

AU - Melchels, F.P.W.

AU - Grijpma, Dirk W.

AU - Feijen, Jan

PY - 2009/12/18

Y1 - 2009/12/18

N2 - Polymer networks were prepared by photocross-linking fumaric acid monoethyl ester (FAME) functionalized, three-armed poly(d,l-lactide) oligomers using N-vinyl-2-pyrrolidone (NVP) as diluent and comonomer. The use of NVP together with FAME-functionalized oligomers resulted in copolymerization at high rates, and networks with gel contents in excess of 90% were obtained. The hydrophilicity of the poly(d,l-lactide) networks increases with increasing amounts of NVP, networks containing 50 wt % of NVP absorbed 40% of water. As the amount of NVP was increased from 30 to 50 wt %, the Young’s modulus after equilibration in water decreased from 0.8 to 0.2 GPa, as opposed to an increase from 1.5 to 2.1 GPa in the dry state. Mouse preosteoblasts readily adhered and spread onto all prepared networks. Using stereolithography, porous structures with a well-defined gyroid architecture were prepared from these novel materials. This allows the preparation of tissue engineering scaffolds with optimized pore architecture and tunable material properties.

AB - Polymer networks were prepared by photocross-linking fumaric acid monoethyl ester (FAME) functionalized, three-armed poly(d,l-lactide) oligomers using N-vinyl-2-pyrrolidone (NVP) as diluent and comonomer. The use of NVP together with FAME-functionalized oligomers resulted in copolymerization at high rates, and networks with gel contents in excess of 90% were obtained. The hydrophilicity of the poly(d,l-lactide) networks increases with increasing amounts of NVP, networks containing 50 wt % of NVP absorbed 40% of water. As the amount of NVP was increased from 30 to 50 wt %, the Young’s modulus after equilibration in water decreased from 0.8 to 0.2 GPa, as opposed to an increase from 1.5 to 2.1 GPa in the dry state. Mouse preosteoblasts readily adhered and spread onto all prepared networks. Using stereolithography, porous structures with a well-defined gyroid architecture were prepared from these novel materials. This allows the preparation of tissue engineering scaffolds with optimized pore architecture and tunable material properties.

KW - METIS-263283

KW - IR-76380

KW - EC Grant Agreement nr.: FP6/500465

U2 - 10.1021/bm801001r

DO - 10.1021/bm801001r

M3 - Article

VL - 10

SP - 214

EP - 210

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

IS - 2

ER -