Functional MRI of the human brain with GRASE-based BOLD contrast

Jorge Jovicich; David G. Norris

doi:10.1002/(SICI)1522-2594(199905)41:5<871::AID-MRM3>3.0.CO;2-O

Functional MRI of the human brain with GRASE-based BOLD contrast

Jorge Jovicich^*, David G. Norris

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

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Abstract

The application of T₂*-weighted gradient and spin-echo (GRASE) imaging was investigated as a method for blood oxygenation level-dependent (BOLD)- based functional magnetic resonance imaging (fMRI). The displaced-echo method was implemented to produce single-shot T₂*-weighted GRASE images. This technique removes the requirement that the Carr-Purcell Meiboom-Gill (CPMG) condition be fulfilled. T₂*-weighted GRASE images that are free from interference artifacts can thus be obtained, hence allowing the possibility of using single-shot GRASE for BOLD-based functional imaging. The method was demonstrated at 3 T and gave robust and reproducible activation-induced signal changes.

Original language	English
Pages (from-to)	871-876
Number of pages	6
Journal	Magnetic resonance in medicine
Volume	41
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1522-2594(199905)41:5<871::AID-MRM3>3.0.CO;2-O
Publication status	Published - 1999
Externally published	Yes

Keywords

Displaced-echo
Functional MRI
GRASE imaging
Template interactive phase encoding

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10.1002/(SICI)1522-2594(199905)41:5<871::AID-MRM3>3.0.CO;2-O

Magnetic Resonance in Med - 1999 - JovicichFinal published version, 189 KB

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AB - The application of T2*-weighted gradient and spin-echo (GRASE) imaging was investigated as a method for blood oxygenation level-dependent (BOLD)- based functional magnetic resonance imaging (fMRI). The displaced-echo method was implemented to produce single-shot T2*-weighted GRASE images. This technique removes the requirement that the Carr-Purcell Meiboom-Gill (CPMG) condition be fulfilled. T2*-weighted GRASE images that are free from interference artifacts can thus be obtained, hence allowing the possibility of using single-shot GRASE for BOLD-based functional imaging. The method was demonstrated at 3 T and gave robust and reproducible activation-induced signal changes.

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KW - Template interactive phase encoding

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Functional MRI of the human brain with GRASE-based BOLD contrast

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Keywords

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