Functional neuronal activity and connectivity within the subthalamic nucleus in Parkinson's disease

M.A.J. Lourens, H.G.E. Meijer, M.F. Contarino, P. van den Munckhof, P.R. Schuurman, S.A. van Gils, L.J. Bour

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Objective: Characterization of the functional neuronal activity and connectivity within the subthalamic nucleus (STN) in patients with Parkinson’s disease (PD).

Methods: Single units were extracted from micro-electrode recording (MER) of 18 PD patients who underwent STN deep brain stimulation (DBS) surgery. The firing rate and pattern of simultaneously recorded spike trains and their coherence were analyzed. To provide a precise functional assignment of position to the observed activities, for each patient we mapped its classified multichannel STN MERs to a generic atlas representation with a sensorimotor part and a remaining part.

Results: Within the sensorimotor part we found significantly higher mean firing rate (P < 0.05) and significantly more burst-like activity (P < 0.05) than within the remaining part. The proportion of significant coherence in the beta band (13–30 Hz) is significantly higher in the sensorimotor part of the STN than elsewhere (P = 0.015).

Conclusions: The STN sensorimotor part distinguishes itself from the remaining part with respect to beta coherence, firing rate and burst-like activity and postoperatively was found as the preferred target area.SignificanceOur firing behavior analysis may help to discriminate the STN sensorimotor part for the placement of the DBS electrode.

Original languageEnglish
Pages (from-to)967-981
Number of pages15
JournalClinical neurophysiology
Volume124
Issue number5
DOIs
Publication statusPublished - May 2013

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Subthalamic Nucleus
Parkinson Disease
Deep Brain Stimulation
Electrodes
Atlases

Keywords

  • EWI-23053
  • Functional connectivity
  • Intraoperative micro-electrode recordings
  • Parkinson’s disease
  • Deep Brain Stimulation
  • Subthalamic nucleus
  • METIS-296290
  • IR-85487
  • Stereotactic surgery

Cite this

Lourens, M.A.J. ; Meijer, H.G.E. ; Contarino, M.F. ; van den Munckhof, P. ; Schuurman, P.R. ; van Gils, S.A. ; Bour, L.J. / Functional neuronal activity and connectivity within the subthalamic nucleus in Parkinson's disease. In: Clinical neurophysiology. 2013 ; Vol. 124, No. 5. pp. 967-981.
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abstract = "Objective: Characterization of the functional neuronal activity and connectivity within the subthalamic nucleus (STN) in patients with Parkinson’s disease (PD).Methods: Single units were extracted from micro-electrode recording (MER) of 18 PD patients who underwent STN deep brain stimulation (DBS) surgery. The firing rate and pattern of simultaneously recorded spike trains and their coherence were analyzed. To provide a precise functional assignment of position to the observed activities, for each patient we mapped its classified multichannel STN MERs to a generic atlas representation with a sensorimotor part and a remaining part.Results: Within the sensorimotor part we found significantly higher mean firing rate (P < 0.05) and significantly more burst-like activity (P < 0.05) than within the remaining part. The proportion of significant coherence in the beta band (13–30 Hz) is significantly higher in the sensorimotor part of the STN than elsewhere (P = 0.015).Conclusions: The STN sensorimotor part distinguishes itself from the remaining part with respect to beta coherence, firing rate and burst-like activity and postoperatively was found as the preferred target area.SignificanceOur firing behavior analysis may help to discriminate the STN sensorimotor part for the placement of the DBS electrode.",
keywords = "EWI-23053, Functional connectivity, Intraoperative micro-electrode recordings, Parkinson’s disease, Deep Brain Stimulation, Subthalamic nucleus, METIS-296290, IR-85487, Stereotactic surgery",
author = "M.A.J. Lourens and H.G.E. Meijer and M.F. Contarino and {van den Munckhof}, P. and P.R. Schuurman and {van Gils}, S.A. and L.J. Bour",
note = "Highlights: A Significantly different firing behavior of single units has been demonstrated in the sensorimotor part of the STN compared to the remaining part in PD patients. {\^a}–º This includes increased mean firing rate, more bursty behavior of neurons and increased interneuronal coherences in the beta band. {\^a}–º Postoperative evaluation of target stimulation areas in the investigated PD patients with DBS shows a significant preference for the sensorimotor part of the STN.",
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Functional neuronal activity and connectivity within the subthalamic nucleus in Parkinson's disease. / Lourens, M.A.J.; Meijer, H.G.E.; Contarino, M.F.; van den Munckhof, P.; Schuurman, P.R.; van Gils, S.A.; Bour, L.J.

In: Clinical neurophysiology, Vol. 124, No. 5, 05.2013, p. 967-981.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Functional neuronal activity and connectivity within the subthalamic nucleus in Parkinson's disease

AU - Lourens, M.A.J.

AU - Meijer, H.G.E.

AU - Contarino, M.F.

AU - van den Munckhof, P.

AU - Schuurman, P.R.

AU - van Gils, S.A.

AU - Bour, L.J.

N1 - Highlights: A Significantly different firing behavior of single units has been demonstrated in the sensorimotor part of the STN compared to the remaining part in PD patients. â–º This includes increased mean firing rate, more bursty behavior of neurons and increased interneuronal coherences in the beta band. â–º Postoperative evaluation of target stimulation areas in the investigated PD patients with DBS shows a significant preference for the sensorimotor part of the STN.

PY - 2013/5

Y1 - 2013/5

N2 - Objective: Characterization of the functional neuronal activity and connectivity within the subthalamic nucleus (STN) in patients with Parkinson’s disease (PD).Methods: Single units were extracted from micro-electrode recording (MER) of 18 PD patients who underwent STN deep brain stimulation (DBS) surgery. The firing rate and pattern of simultaneously recorded spike trains and their coherence were analyzed. To provide a precise functional assignment of position to the observed activities, for each patient we mapped its classified multichannel STN MERs to a generic atlas representation with a sensorimotor part and a remaining part.Results: Within the sensorimotor part we found significantly higher mean firing rate (P < 0.05) and significantly more burst-like activity (P < 0.05) than within the remaining part. The proportion of significant coherence in the beta band (13–30 Hz) is significantly higher in the sensorimotor part of the STN than elsewhere (P = 0.015).Conclusions: The STN sensorimotor part distinguishes itself from the remaining part with respect to beta coherence, firing rate and burst-like activity and postoperatively was found as the preferred target area.SignificanceOur firing behavior analysis may help to discriminate the STN sensorimotor part for the placement of the DBS electrode.

AB - Objective: Characterization of the functional neuronal activity and connectivity within the subthalamic nucleus (STN) in patients with Parkinson’s disease (PD).Methods: Single units were extracted from micro-electrode recording (MER) of 18 PD patients who underwent STN deep brain stimulation (DBS) surgery. The firing rate and pattern of simultaneously recorded spike trains and their coherence were analyzed. To provide a precise functional assignment of position to the observed activities, for each patient we mapped its classified multichannel STN MERs to a generic atlas representation with a sensorimotor part and a remaining part.Results: Within the sensorimotor part we found significantly higher mean firing rate (P < 0.05) and significantly more burst-like activity (P < 0.05) than within the remaining part. The proportion of significant coherence in the beta band (13–30 Hz) is significantly higher in the sensorimotor part of the STN than elsewhere (P = 0.015).Conclusions: The STN sensorimotor part distinguishes itself from the remaining part with respect to beta coherence, firing rate and burst-like activity and postoperatively was found as the preferred target area.SignificanceOur firing behavior analysis may help to discriminate the STN sensorimotor part for the placement of the DBS electrode.

KW - EWI-23053

KW - Functional connectivity

KW - Intraoperative micro-electrode recordings

KW - Parkinson’s disease

KW - Deep Brain Stimulation

KW - Subthalamic nucleus

KW - METIS-296290

KW - IR-85487

KW - Stereotactic surgery

U2 - 10.1016/j.clinph.2012.10.018

DO - 10.1016/j.clinph.2012.10.018

M3 - Article

VL - 124

SP - 967

EP - 981

JO - Clinical neurophysiology

JF - Clinical neurophysiology

SN - 1388-2457

IS - 5

ER -