Functional optical coherence tomography of pigmented lesions

R. Wessels, R. Wessels, D.M. de Bruin, G.N. Relyveld, D.J. Faber, A.D. Vincent, J. Sanders, Ton van Leeuwen, Theo J.M. Ruers

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)


Background Cutaneous melanomas are diagnosed worldwide in 231 130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient (μoct). Objective We hypothesize that OCT images of nevi will differ qualitatively and quantitatively from melanomas. Methods Forty lesions from 33 consecutive patients were imaged with OCT. After data acquisition, excision was performed. Epidermal layer thickness was measured and values of μoct were extracted from 200 OCT images of pigmented lesions. Results Morphologically, absence of the lower border of the lesion was characteristic for melanoma (P = 0.02). Also, the μoct was different between benign and malignant lesions (P = 0.02). There were no differences in epidermal layer thickness of benign lesions and melanoma. Conclusion Although this preliminary study comprised a small number of patients, quantitative analysis of OCT images in pigmented skin lesions give valuable additional information about lesions characteristics. When using the attenuation coefficient, it might be possible to distinguish between benign lesions and melanomas.
Original languageEnglish
Pages (from-to)738-744
JournalJournal of the European Academy of Dermatology and Venereology
Issue number4
Publication statusPublished - 29 Aug 2015


  • IR-95646
  • METIS-307905


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