Functionalized calixspherands: synthesis and peptide coupling

Wouter I. Iwema Bakker, Marijke Haas, Herman J. den Hertog Jr., Willem Verboom, Dick de Zeeuw, Andries P. Bruins, David N. Reinhoudt

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Abstract

Calixspherands, like 1, form kinetically stable complexes with alkali metal cations. For practical in vivo applications coupling of these complexes with carrier molecules is mandatory. Therefore, a general method for the synthesis of functionalized.calixspherand 17 was developed starting from functionalized m-terphenyl 10 and p-tert-butylcalix[ 4]arene (14). The functionalized m-terphenyl was synthesized by a Suzuki-,cross-coupling reaction. Functionalized calixspherand 17 has been coupled to a low molecular weight protein.
Original languageEnglish
Pages (from-to)972-976
JournalJournal of organic chemistry
Volume59
Issue number5
DOIs
Publication statusPublished - 1994

Keywords

  • METIS-106589
  • IR-12289

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    Iwema Bakker, W. I., Haas, M., den Hertog Jr., H. J., Verboom, W., de Zeeuw, D., Bruins, A. P., & Reinhoudt, D. N. (1994). Functionalized calixspherands: synthesis and peptide coupling. Journal of organic chemistry, 59(5), 972-976. https://doi.org/10.1021/jo00084a011