Functionalized calixspherands: synthesis and peptide coupling

Wouter I. Iwema Bakker, Marijke Haas, Herman J. den Hertog Jr., Willem Verboom, Dick de Zeeuw, Andries P. Bruins, David N. Reinhoudt

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
151 Downloads (Pure)


Calixspherands, like 1, form kinetically stable complexes with alkali metal cations. For practical in vivo applications coupling of these complexes with carrier molecules is mandatory. Therefore, a general method for the synthesis of functionalized.calixspherand 17 was developed starting from functionalized m-terphenyl 10 and p-tert-butylcalix[ 4]arene (14). The functionalized m-terphenyl was synthesized by a Suzuki-,cross-coupling reaction. Functionalized calixspherand 17 has been coupled to a low molecular weight protein.
Original languageEnglish
Pages (from-to)972-976
JournalThe journal of organic chemistry
Issue number5
Publication statusPublished - 1994


  • METIS-106589
  • IR-12289


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