Gallium-containing polymer brush film as efficient supported Lewis acid catalyst in a glass microreactor

Rajesh Munirathinam, Roberto Ricardi, Richard J.M. Egberink, Jurriaan Huskens, Michael Holtkamp, Herbert Wormeester, U. Karst, Willem Verboom

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Polystyrene sulfonate polymer brushes, grown on the interior of the microchannels in a microreactor, have been used for the anchoring of gallium as a Lewis acid catalyst. Initially, gallium-containing polymer brushes were grown on a flat silicon oxide surface and were characterized by FTIR, ellipsometry, and X-ray photoelectron spectroscopy (XPS). XPS revealed the presence of one gallium per 2–3 styrene sulfonate groups of the polymer brushes. The catalytic activity of the Lewis acid-functionalized brushes in a microreactor was demonstrated for the dehydration of oximes, using cinnamaldehyde oxime as a model substrate, and for the formation of oxazoles by ring closure of ortho-hydroxy oximes. The catalytic activity of the microreactor could be maintained by periodic reactivation by treatment with GaCl3.
Original languageUndefined
Pages (from-to)1698-1704
Number of pages7
JournalBeilstein journal of organic chemistry
Publication statusPublished - 2013


  • METIS-298047
  • IR-89989

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