Generalized periodic discharges: Pathophysiology and clinical considerations

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
103 Downloads (Pure)


Generalized periodic discharges (GPDs) are commonly encountered in metabolic encephalopathy and cerebral hypoxia/ischemia. The clinical significance of this EEG pattern is indistinct, and it is unclear whether treatment with antiepileptic drugs is beneficial. In this study, we discuss potential pathophysiological mechanisms. Based on the literature, supplemented with simulations in a minimal computational model, we conclude that selective synaptic failure or neuronal damage of inhibitory interneurons, leading to disinhibition of excitatory pyramidal cells, presumably plays a critical role. Reversibility probably depends on the potential for functional recovery of these interneurons. Whether antiepileptic drugs are helpful for regaining function is unclear
Original languageEnglish
Pages (from-to)228-233
JournalEpilepsy & behavior
Publication statusPublished - 2 May 2015


  • METIS-310654
  • IR-96362

Fingerprint Dive into the research topics of 'Generalized periodic discharges: Pathophysiology and clinical considerations'. Together they form a unique fingerprint.

Cite this