Generation of monodisperse microemulsions in the colloidal range and stabilized monodisperse microbubbles with diameters of 5 microns using two different types of micro fluidic devices

E. Castro-Hernández, W. Van Hoeve, F. Campo-Cortés, D. Lohse, J. M. Gordillo*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Here we propose two different ways to generate either monodisperse microemulsions or monodisperse microbubbles. The first of these techniques, the coflow configuration, consists of a flow rate Q i of a fluid with a viscosity μ i that discharges into an immiscible liquid of viscosity μ o that flows in parallel with the axis of the injector. When operating under the appropriate conditions, concentrated emulsions composed of micronsized drops with a narrow size distribution can be generated. Nevertheless, this procedure is not equally valid to generate the type of monodisperse bubbles required in many different pharmaceutical, medical and material science applications. As a consequence, we propose a variant of the coflow configuration implemented in a two-dimensional PDMS device for the production of ∼ 5 μm bubbles with a polydispersity index below 5% at high production rates (> 10 5 bubbles/s).

Original languageEnglish
Title of host publicationNanotechnology 2012
Subtitle of host publicationElectronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
Pages321-324
Number of pages4
Publication statusPublished - 17 Aug 2012
Event2012 NSTI Nanotechnology Conference and Expo - Santa Clara, United States
Duration: 18 Jun 201221 Jun 2012

Publication series

NameTechnical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012

Conference

Conference2012 NSTI Nanotechnology Conference and Expo
CountryUnited States
CitySanta Clara
Period18/06/1221/06/12

Fingerprint

Fluidic devices
Microemulsions
Viscosity
Polydispersity
Materials science
Emulsions
Discharge (fluid mechanics)
Drug products
Flow rate
Fluids
Liquids
Pharmaceutical Preparations

Keywords

  • Bubbles
  • Coflow
  • Contrast agents
  • Droplets
  • Microemulsions

Cite this

Castro-Hernández, E., Van Hoeve, W., Campo-Cortés, F., Lohse, D., & Gordillo, J. M. (2012). Generation of monodisperse microemulsions in the colloidal range and stabilized monodisperse microbubbles with diameters of 5 microns using two different types of micro fluidic devices. In Nanotechnology 2012: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 (pp. 321-324). (Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012).
Castro-Hernández, E. ; Van Hoeve, W. ; Campo-Cortés, F. ; Lohse, D. ; Gordillo, J. M. / Generation of monodisperse microemulsions in the colloidal range and stabilized monodisperse microbubbles with diameters of 5 microns using two different types of micro fluidic devices. Nanotechnology 2012: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012. 2012. pp. 321-324 (Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012).
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abstract = "Here we propose two different ways to generate either monodisperse microemulsions or monodisperse microbubbles. The first of these techniques, the coflow configuration, consists of a flow rate Q i of a fluid with a viscosity μ i that discharges into an immiscible liquid of viscosity μ o that flows in parallel with the axis of the injector. When operating under the appropriate conditions, concentrated emulsions composed of micronsized drops with a narrow size distribution can be generated. Nevertheless, this procedure is not equally valid to generate the type of monodisperse bubbles required in many different pharmaceutical, medical and material science applications. As a consequence, we propose a variant of the coflow configuration implemented in a two-dimensional PDMS device for the production of ∼ 5 μm bubbles with a polydispersity index below 5{\%} at high production rates (> 10 5 bubbles/s).",
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Castro-Hernández, E, Van Hoeve, W, Campo-Cortés, F, Lohse, D & Gordillo, JM 2012, Generation of monodisperse microemulsions in the colloidal range and stabilized monodisperse microbubbles with diameters of 5 microns using two different types of micro fluidic devices. in Nanotechnology 2012: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012. Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012, pp. 321-324, 2012 NSTI Nanotechnology Conference and Expo, Santa Clara, United States, 18/06/12.

Generation of monodisperse microemulsions in the colloidal range and stabilized monodisperse microbubbles with diameters of 5 microns using two different types of micro fluidic devices. / Castro-Hernández, E.; Van Hoeve, W.; Campo-Cortés, F.; Lohse, D.; Gordillo, J. M.

Nanotechnology 2012: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012. 2012. p. 321-324 (Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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T1 - Generation of monodisperse microemulsions in the colloidal range and stabilized monodisperse microbubbles with diameters of 5 microns using two different types of micro fluidic devices

AU - Castro-Hernández, E.

AU - Van Hoeve, W.

AU - Campo-Cortés, F.

AU - Lohse, D.

AU - Gordillo, J. M.

PY - 2012/8/17

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N2 - Here we propose two different ways to generate either monodisperse microemulsions or monodisperse microbubbles. The first of these techniques, the coflow configuration, consists of a flow rate Q i of a fluid with a viscosity μ i that discharges into an immiscible liquid of viscosity μ o that flows in parallel with the axis of the injector. When operating under the appropriate conditions, concentrated emulsions composed of micronsized drops with a narrow size distribution can be generated. Nevertheless, this procedure is not equally valid to generate the type of monodisperse bubbles required in many different pharmaceutical, medical and material science applications. As a consequence, we propose a variant of the coflow configuration implemented in a two-dimensional PDMS device for the production of ∼ 5 μm bubbles with a polydispersity index below 5% at high production rates (> 10 5 bubbles/s).

AB - Here we propose two different ways to generate either monodisperse microemulsions or monodisperse microbubbles. The first of these techniques, the coflow configuration, consists of a flow rate Q i of a fluid with a viscosity μ i that discharges into an immiscible liquid of viscosity μ o that flows in parallel with the axis of the injector. When operating under the appropriate conditions, concentrated emulsions composed of micronsized drops with a narrow size distribution can be generated. Nevertheless, this procedure is not equally valid to generate the type of monodisperse bubbles required in many different pharmaceutical, medical and material science applications. As a consequence, we propose a variant of the coflow configuration implemented in a two-dimensional PDMS device for the production of ∼ 5 μm bubbles with a polydispersity index below 5% at high production rates (> 10 5 bubbles/s).

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KW - Contrast agents

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Castro-Hernández E, Van Hoeve W, Campo-Cortés F, Lohse D, Gordillo JM. Generation of monodisperse microemulsions in the colloidal range and stabilized monodisperse microbubbles with diameters of 5 microns using two different types of micro fluidic devices. In Nanotechnology 2012: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012. 2012. p. 321-324. (Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012).